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Status: Bibliographieeintrag

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Verfasst von:Mirian, Christian [VerfasserIn]   i
 Gerds, Thomas A. [VerfasserIn]   i
 Pedersen, Maria M. [VerfasserIn]   i
 de Ridder, Mischa [VerfasserIn]   i
 Balm, Alfons [VerfasserIn]   i
 Mattavelli, Davide [VerfasserIn]   i
 Piazza, Cesare [VerfasserIn]   i
 Jensen, Lasse R. [VerfasserIn]   i
 Balasubramanian, Deepak [VerfasserIn]   i
 Subramaniam, Narayana [VerfasserIn]   i
 Dokhe, Yogesh [VerfasserIn]   i
 Thankappan, Krishnakumar [VerfasserIn]   i
 Iyer, Subramania [VerfasserIn]   i
 Karam, Sana D. [VerfasserIn]   i
 Wiegand, Susanne [VerfasserIn]   i
 Feeley, Linda [VerfasserIn]   i
 Milross, Chris [VerfasserIn]   i
 Gao, Kan [VerfasserIn]   i
 Palme, Carsten E. [VerfasserIn]   i
 Low, Tsu-Hui (Hubert) [VerfasserIn]   i
 Gupta, Ruta [VerfasserIn]   i
 Freudlsperger, Christian [VerfasserIn]   i
 Moratin, Julius [VerfasserIn]   i
 Sheahan, Patrick [VerfasserIn]   i
 Clark, Jonathan [VerfasserIn]   i
 Ovesen, Therese [VerfasserIn]   i
Titel:Metrics of pN-staging in oral squamous cell carcinoma
Titelzusatz:an analysis of 1,905 patients
Verf.angabe:Christian Mirian, Thomas A. Gerds, Maria M. Pedersen, Mischa de Ridder, Alfons Balm, Davide Mattavelli, Cesare Piazza, Lasse R. Jensen, Deepak Balasubramanian, Narayana Subramaniam, Yogesh Dokhe, Krishnakumar Thankappan, Subramania Iyer, Sana D. Karam, Susanne Wiegand, Linda Feeley, Chris Milross, Kan Gao, Carsten E. Palme, Tsu-Hui (Hubert) Low, Ruta Gupta, Christian Freudlsperger, Julius Moratin, Patrick Sheahan, Jonathan Clark, Therese Ovesen
E-Jahr:2021
Jahr:19 April 2021
Umfang:9 S.
Fussnoten:Gesehen am 26.08.2021
Titel Quelle:Enthalten in: European journal of cancer
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1992
Jahr Quelle:2021
Band/Heft Quelle:150(2021) vom: Juni, Seite 33-41
ISSN Quelle:1879-0852
Abstract:Background - We aimed to compare the predictive performance of pN-categories in oral squamous cell carcinoma (OSCC) encompassing the most recent 8th edition (TNM8), its predecessor (TNM7), and a newly proposed algorithm (pN-N+), which classifies patients according to the number of positive lymph nodes and extranodal extension. - Methods - Consecutive, primary OSCC patients from seven previously published cohorts were included and classified according to the three pN-classifications: TNM7, TNM8 and pN-N+. Overall survival probabilities were summarised with the Kaplan-Meier method. We added each of the three metrics to a Cox regression adjusted for pT-category, lymph nodal yield, age, sex, radiotherapy and chemotherapy, and trained these models in one institution. We evaluated the predictive performance in the remaining six institutions and assessed the predicted 5-year risk of death using the area under the receiver operating characteristics curve (AUC) and Brier scores. - Results - All 1,905 included patients were classified according to TNM7 and pN-N+. A subset of 1,575 patients was additionally classified according to TNM8, leading to upstaging in 27.0%. The pN-N+ ranked overall best determined by the obtained AUC and Brier scores. In contrast to pN-N+, TNM7 and TNM8 both suffered from disproportionate patient distribution across pN-categories and poor pN-categorial discrimination on overall survival. - Conclusions - The TNM8 pN-classification designates a larger subset to more advanced disease stages but failed to show improvement of its predictive performance compared to TNM7. The pN-categories of TNM7/8 are disproportionate and inconsistently discriminated. The pN-N+ conveyed the best measures of prognosis and should be considered in future TNM iterations.
DOI:doi:10.1016/j.ejca.2021.03.019
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ejca.2021.03.019
 Volltext: https://www.sciencedirect.com/science/article/pii/S0959804921001866
 DOI: https://doi.org/10.1016/j.ejca.2021.03.019
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:AJCC
 Classification
 Epidemiology
 Head and neck oncology
 Lymph nodal density
 Lymph nodal yield
 Oral oncology
 OSCC
 pN-staging
 TNM
K10plus-PPN:1767903049
Verknüpfungen:→ Zeitschrift

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