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Verfasst von:Herold, Christina [VerfasserIn]   i
 Duval, Céline Z. [VerfasserIn]   i
 Schröder, Johannes [VerfasserIn]   i
Titel:Neurological soft signs and cognition in the late course of chronic schizophrenia
Titelzusatz:a longitudinal study
Verf.angabe:Christina J. Herold, Céline Z. Duval, Johannes Schröder
E-Jahr:2020
Jahr:16 May 2020
Fussnoten:Gesehen am 31.08.2021
Titel Quelle:Enthalten in: European archives of psychiatry and clinical neuroscience
Ort Quelle:Darmstadt : Steinkopff, 1868
Jahr Quelle:2021
Band/Heft Quelle:271(2021), 8, Seite 1465-1473
ISSN Quelle:1433-8491
Abstract:Neurological soft signs (NSS) are minor (‘soft’) neurological abnormalities in sensory and motor performances, which are frequently reported in patients with schizophrenia at any stage of their illness. It has been demonstrated that NSS vary in the clinical course of the disorder: longitudinally NSS decrease in parallel with remission of psychopathological symptoms, an effect which mainly applies to patients with a remitting course. These findings are primarily based on patients with a first episode of the disorder, while the course of NSS in patients with chronic schizophrenia and persisting symptoms is rather unknown. Therefore, we investigated NSS twice in 21 patients with chronic schizophrenia (initial mean duration of illness: 23 ± 11 years) with a mean follow-up interval of 7 years. NSS were evaluated by the Heidelberg Scale, established instruments were used to rate neuropsychological performance and psychopathological symptoms. NSS showed significant increases on the subscales “motor coordination” and “integrative functions”, while positive and negative symptoms, including apathy, showed only minor, non-significant changes. Verbal memory, verbal fluency, and cognitive flexibility along with severity of global cognitive deficits demonstrated a significant deterioration. Regression analyses identified executive dysfunction (cognitive flexibility and verbal fluency) at baseline as significant predictors of NSS increase at follow-up. Our findings indicate that NSS deteriorate in the long-term course of chronic schizophrenia. This effect may be accounted for by a decrease of executive functions and logical memory, which can be attributed to premature brain aging.
DOI:doi:10.1007/s00406-020-01138-7
URL:kostenfrei: Volltext: https://doi.org/10.1007/s00406-020-01138-7
 DOI: https://doi.org/10.1007/s00406-020-01138-7
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1768107319
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