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| Verfasst von: | Moratin, Julius [VerfasserIn]  |
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| | Mock, Andreas [VerfasserIn] |
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| | Steen, Sonja [VerfasserIn] |
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| | Semmelmayer, Karl [VerfasserIn] |
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| | Flechtenmacher, Christa [VerfasserIn] |
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| | Plath, Karim [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Krauß, Jürgen [VerfasserIn] |
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| | Hoffmann, Jürgen [VerfasserIn] |
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| | Freier, Kolja [VerfasserIn] |
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| | Horn, Dominik [VerfasserIn] |
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| | Heß, Jochen [VerfasserIn] |
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| | Freudlsperger, Christian [VerfasserIn] |
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| Titel: | Digital pathology scoring of immunohistochemical staining reliably identifies prognostic markers and anatomical associations in a large cohort of oral cancers |
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| Verf.angabe: | Julius Moratin, Andreas Mock, Sonja Obradovic, Karl Metzger, Christa Flechtenmacher, Karim Zaoui, Stefan Fröhling, Dirk Jäger, Jürgen Krauss, Jürgen Hoffmann, Kolja Freier, Dominik Horn, Jochen Hess and Christian Freudlsperger |
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| E-Jahr: | 2021 |
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| Jahr: | 29 July 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 31.08.2021 |
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| Titel Quelle: | Enthalten in: Frontiers in oncology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 11(2021) vom: 29. Juli, Artikel-ID 712944, Seite 1-11 |
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| ISSN Quelle: | 2234-943X |
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| Abstract: | Utilizing digital pathology algorithms for the objective quantification of immunohistochemical staining, this study aimed to identify robust prognostic biomarkers for oral cancer. Tissue microarrays with specimens of a large cohort of oral squamous cell carcinoma (n=222) were immunohistochemically stained to determine the expression of PD-L1, EGFR, and COX-2 and the amount of infiltrating NK cells and CD8-positive T cells. Immunoreactivity scores were assessed using both a classical manual scoring procedure and a digital semi-automatic approach using QuPath. Digital scoring was successful in quantifying the expression levels of different prognostic biomarkers (CD8: p<0.001; NK cells: p=0.002, PD-L1: p=0.026) and high levels of concordance with manual scoring results were observed. A combined score integrating EGFR expression, neck node status and immune cell signatures with a significant impact on overall and progression-free survival was identified (p<0.001). These data may contribute to the ongoing research on the identification of reliable and clinically relevant biomarkers for the individualization of primary and adjuvant treatment in oral cancer. |
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| DOI: | doi:10.3389/fonc.2021.712944 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.3389/fonc.2021.712944 |
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| | kostenfrei: Volltext: https://www.frontiersin.org/article/10.3389/fonc.2021.712944 |
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| | DOI: https://doi.org/10.3389/fonc.2021.712944 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1768117543 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Digital pathology scoring of immunohistochemical staining reliably identifies prognostic markers and anatomical associations in a large cohort of oral cancers / Moratin, Julius [VerfasserIn]; 29 July 2021 (Online-Ressource)
