| |  Online-Ressource |
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| Verfasst von: | Selberg, Lorenz [VerfasserIn]  |
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| | Stadtherr, Peter [VerfasserIn] |
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| | Dietrich, Sascha [VerfasserIn] |
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| | Tran, Thuong Hien [VerfasserIn] |
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| | Luft, Thomas [VerfasserIn] |
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| | Hegenbart, Ute [VerfasserIn] |
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| | Bondong, Andrea [VerfasserIn] |
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| | Meißner, Julia [VerfasserIn] |
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| | Liebers, Nora [VerfasserIn] |
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| | Schmitt, Michael [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| Titel: | The impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma |
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| Titelzusatz: | an intent-to-transplant analysis |
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| Verf.angabe: | Lorenz Selberg, Peter Stadtherr, Sascha Dietrich, T. Hien Tran, Thomas Luft, Ute Hegenbart, Andrea Bondong, Julia Meissner, Nora Liebers, Michael Schmitt, Anthony Dick Ho, Carsten Müller-Tidow, Peter Dreger |
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| Jahr: | 2021 |
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| Umfang: | 8 S. |
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| Fussnoten: | Published online: 18 June 2020 ; Gesehen am 07.09.2021 |
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| Titel Quelle: | Enthalten in: Bone marrow transplantation |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 56(2021), 1, Seite 30-37 |
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| ISSN Quelle: | 1476-5365 |
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| Abstract: | Purpose of this single-centre retrospective study was to assess the outcome of allogeneic hematopoietic cell transplantation (alloHCT) for relapsed/refractory (r/r) non-Hodgkin lymphoma (NHL) by intent-to-transplant (ITT). Included were all consecutive patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and peripheral T-cell lymphoma (PTCL) for whom a donor search was performed between 2004 and 2018. Primary endpoint was overall survival (OS) measured from search initiation. A donor search was initiated for 189 patients (DLBCL 61, FL 32, MCL 43, and PTCL 53), with 76% of the patients having active disease. OS at 5 years after search initiation for DLBCL, FL, MCL, and PTCL was 26%, 44%, 52%, and 50%, respectively. AlloHCT was performed in 137 patients (72%; DLBCL 64%). Main reason for not undergoing alloHCT was disease progression, whereas donor unavailability accounted for only 4% of pretransplantation failures. These results suggest that survival of patients with r/r NHL entering the alloHCT route may be overestimated by a factor of 1.2-1.4 if based on actually transplanted patients only. This effect should be taken into account when using alloHCT as benchmark for new therapeutic approaches for the treatment of poor-risk NHL. |
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| DOI: | doi:10.1038/s41409-020-0976-4 |
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| URL: | Volltext ; Verlag: https://doi.org/10.1038/s41409-020-0976-4 |
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| | Volltext: https://www.nature.com/articles/s41409-020-0976-4 |
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| | DOI: https://doi.org/10.1038/s41409-020-0976-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1769571515 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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¬The¬ impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma / Selberg, Lorenz [VerfasserIn]; 2021 (Online-Ressource)
