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Verfasst von:Enko, Dietmar [VerfasserIn]   i
 Meinitzer, Andreas [VerfasserIn]   i
 Scherberich, Jürgen E. [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
 Herrmann, Markus [VerfasserIn]   i
 Artinger, Katharina [VerfasserIn]   i
 Rosenkranz, Alexander R. [VerfasserIn]   i
 Zitta, Sabine [VerfasserIn]   i
Titel:Individual uromodulin serum concentration is independent of glomerular filtration rate in healthy kidney donors
Verf.angabe:Dietmar Enko, Andreas Meinitzer, Jürgen E. Scherberich, Winfried März, Markus Herrmann, Katharina Artinger, Alexander R. Rosenkranz und Sabine Zitta
Jahr:2021
Umfang:8 S.
Fussnoten:Veröffentlicht von De Gruyter 13. Oktober 2020 ; Gesehen am 08.09.2021
Titel Quelle:Enthalten in: Clinical chemistry and laboratory medicine
Ort Quelle:Berlin [u.a.] : De Gruyter, 1998
Jahr Quelle:2021
Band/Heft Quelle:59(2021), 3, Seite 563-570
ISSN Quelle:1437-4331
Abstract:Objectives The mucoprotein uromodulin is considered to correlate with glomerular filtration rates (GFR) in patients with chronic kidney disease (CKD). Here we investigated how serum uromodulin is associated with measured GFR using inulin-clearance and GFR estimated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation in healthy subjects. Methods We assessed possible correlations between uromodulin serum concentrations, inulin-GFR and CKD-EPI-GFR in a well characterized study cohort of 112 healthy living kidney donors with two kidneys before and 64 with one kidney after kidney donation. A subgroup of 32 individuals, which presented data before and after nephrectomy, was assessed separately. Results All 112 healthy living kidney donors with two kidneys revealed individual serum uromodulin concentrations between 60.1 and 450.5 µg/L. Sixty-four healthy kidney donors after nephrectomy had significantly lower median (interquartile range) serum uromodulin concentrations (124 [101-166] vs. 185 [152-238] µg/L), inulin-GFR (67.3 [60.6-74.6] vs. 93.5 [82.1-104.4] mL/min/1.73 m 2 ), and CKD-EPI-GFR (61.2 [53.1-69.7] vs. 88.6 [80.0-97.1] mL/min/1.73 m 2 ) as compared to the 112 donors before donation (p<0.001). The subgroup of 32 subjects, which presented data before and after nephrectomy, showed almost the same pattern of kidney function. No statistically relevant associations were found between serum uromodulin and inulin-GFR or CKD-EPI-GFR regarding this healthy population. Conclusions These novel findings indicate that - in contrast to patients with CKD - serum uromodulin concentrations are not correlated with measured and estimated GFR in healthy individuals.
DOI:doi:10.1515/cclm-2020-0894
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1515/cclm-2020-0894
 Volltext: https://www.degruyter.com/document/doi/10.1515/cclm-2020-0894/html
 DOI: https://doi.org/10.1515/cclm-2020-0894
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:living kidney donors
 measured glomerular filtration rate
 serum uromodulin
K10plus-PPN:1769695753
Verknüpfungen:→ Zeitschrift

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