Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Sommerkamp, Pia [VerfasserIn]  |
|---|
| | Cabezas Wallscheid, Nina [VerfasserIn] |
|---|
| | Trumpp, Andreas [VerfasserIn] |
|---|
| Titel: | Review alternative polyadenylation in stem cell self-renewal and differentiation |
|---|
| Verf.angabe: | Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 11 May 2021 |
|---|
| Umfang: | 13 S. |
|---|
| Teil: | volume:27 |
|---|
| | year:2021 |
|---|
| | number:7 |
|---|
| | pages:660-672 |
|---|
| | extent:13 |
|---|
| Fussnoten: | Gesehen am 10.09.2021 |
|---|
| Titel Quelle: | Enthalten in: Trends in molecular medicine |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 2001 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 27(2021), 7, Seite 660-672 |
|---|
| ISSN Quelle: | 1471-499X |
|---|
| Abstract: | Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3 '-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3 '-UTRs, whereas proliferative stem/progenitor cells exhibit 3 '-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine. |
|---|
| DOI: | doi:10.1016/j.molmed.2021.04.006 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.molmed.2021.04.006 |
|---|
| | Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2 ... |
|---|
| | DOI: https://doi.org/10.1016/j.molmed.2021.04.006 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | 3' untranslated regions |
|---|
| | 3'-end cleavage |
|---|
| | c-myc |
|---|
| | cleavage factor-i |
|---|
| | gene-expression |
|---|
| | neuronal differentiation |
|---|
| | pre-messenger-rna |
|---|
| | protein |
|---|
| | regenerative medicine |
|---|
| | signal |
|---|
| K10plus-PPN: | 1770007040 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Review alternative polyadenylation in stem cell self-renewal and differentiation / Sommerkamp, Pia [VerfasserIn]; 11 May 2021 (Online-Ressource)
68778679
