Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Sommerkamp, Pia [VerfasserIn]  |
| Cabezas Wallscheid, Nina [VerfasserIn]  |
| Trumpp, Andreas [VerfasserIn]  |
Titel: | Review alternative polyadenylation in stem cell self-renewal and differentiation |
Verf.angabe: | Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp |
E-Jahr: | 2021 |
Jahr: | 11 May 2021 |
Umfang: | 13 S. |
Teil: | volume:27 |
| year:2021 |
| number:7 |
| pages:660-672 |
| extent:13 |
Fussnoten: | Gesehen am 10.09.2021 |
Titel Quelle: | Enthalten in: Trends in molecular medicine |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 2001 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 27(2021), 7, Seite 660-672 |
ISSN Quelle: | 1471-499X |
Abstract: | Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3 '-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3 '-UTRs, whereas proliferative stem/progenitor cells exhibit 3 '-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine. |
DOI: | doi:10.1016/j.molmed.2021.04.006 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.molmed.2021.04.006 |
| Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2 ... |
| DOI: https://doi.org/10.1016/j.molmed.2021.04.006 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 3' untranslated regions |
| 3'-end cleavage |
| c-myc |
| cleavage factor-i |
| gene-expression |
| neuronal differentiation |
| pre-messenger-rna |
| protein |
| regenerative medicine |
| signal |
K10plus-PPN: | 1770007040 |
Verknüpfungen: | → Zeitschrift |
Review alternative polyadenylation in stem cell self-renewal and differentiation / Sommerkamp, Pia [VerfasserIn]; 11 May 2021 (Online-Ressource)
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