| Online-Ressource |
Verfasst von: | Jamann, Nora [VerfasserIn]  |
| Dannehl, Dominik [VerfasserIn]  |
| Lehmann, Nadja [VerfasserIn]  |
| Wagener, Jan Robin [VerfasserIn]  |
| Thielemann, Corinna [VerfasserIn]  |
| Schultz, Christian [VerfasserIn]  |
| Staiger, Jochen F. [VerfasserIn]  |
| Kole, Maarten H. P. [VerfasserIn]  |
| Engelhardt, Maren [VerfasserIn]  |
Titel: | Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex |
Verf.angabe: | Nora Jamann, Dominik Dannehl, Nadja Lehmann, Robin Wagener, Corinna Thielemann, Christian Schultz, Jochen Staiger, Maarten H.P. Kole and Maren Engelhardt |
E-Jahr: | 2021 |
Jahr: | 04 January 2021 |
Umfang: | 14 S. |
Fussnoten: | Gesehen am 16.09.2021 |
Titel Quelle: | Enthalten in: Nature Communications |
Ort Quelle: | [London] : Springer Nature, 2010 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 12(2021), Artikel-ID 23, Seite 1-14 |
ISSN Quelle: | 2041-1723 |
Abstract: | The axon initial segment (AIS) is a critical microdomain for action potential initiation and implicated in the regulation of neuronal excitability during activity-dependent plasticity. While structural AIS plasticity has been suggested to fine-tune neuronal activity when network states change, whether it acts in vivo as a homeostatic regulatory mechanism in behaviorally relevant contexts remains poorly understood. Using the mouse whisker-to-barrel pathway as a model system in combination with immunofluorescence, confocal analysis and electrophysiological recordings, we observed bidirectional AIS plasticity in cortical pyramidal neurons. Furthermore, we find that structural and functional AIS remodeling occurs in distinct temporal domains: Long-term sensory deprivation elicits an AIS length increase, accompanied with an increase in neuronal excitability, while sensory enrichment results in a rapid AIS shortening, accompanied by a decrease in action potential generation. Our findings highlight a central role of the AIS in the homeostatic regulation of neuronal input-output relations. |
DOI: | doi:10.1038/s41467-020-20232-x |
URL: | kostenfrei: Volltext: https://doi.org/10.1038/s41467-020-20232-x |
| kostenfrei: Volltext: https://www.nature.com/articles/s41467-020-20232-x |
| DOI: https://doi.org/10.1038/s41467-020-20232-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1770807764 |
Verknüpfungen: | → Zeitschrift |
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Lokale URL UB: | Zum Volltext |
Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex / Jamann, Nora [VerfasserIn]; 04 January 2021 (Online-Ressource)