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Verfasst von:Wolff, Michael von [VerfasserIn]   i
 Rösner, Sabine [VerfasserIn]   i
 Germeyer, Ariane [VerfasserIn]   i
 Jauckus, Julia [VerfasserIn]   i
 Griesinger, G. [VerfasserIn]   i
 Strowitzki, Thomas [VerfasserIn]   i
Titel:Intrauterine instillation of diluted seminal plasma at oocyte pick-up does not increase the IVF pregnancy rate
Titelzusatz:a double-blind, placebo controlled, randomized study
Verf.angabe:M. von Wolff, S. Rösner, A. Germeyer, J. Jauckus, G. Griesinger, and T. Strowitzki
E-Jahr:2013
Jahr:17 September 2013
Umfang:6 S.
Teil:volume:28
 year:2013
 number:12
 pages:3247-3252
 extent:6
Fussnoten:Gesehen am 16.09.2021
Titel Quelle:Enthalten in: Human reproduction
Ort Quelle:Oxford : Oxford Univ. Press, 1986
Jahr Quelle:2013
Band/Heft Quelle:28(2013), 12, Seite 3247-3252
ISSN Quelle:1460-2350
Abstract:Does intrauterine application of diluted seminal plasma (SP) at the time of ovum pick-up improve the pregnancy rate by ≥14% in IVF treatment?Intrauterine instillation of diluted SP at the time of ovum pick-up is unlikely to increase the pregnancy rate by ≥14% in IVF.SP modulates endometrial function, and sexual intercourse around the time of embryo transfer has been suggested to increase the likelihood of pregnancy. A previous randomized double-blind pilot study demonstrated a strong trend towards increased pregnancy rates following the intracervical application of undiluted SP. As this study was not conclusive and as the finding could have been confounded by sexual intercourse, the intrauterine application of diluted SP was investigated in the present trial.A single-centre, prospective, double-blind, placebo-controlled, randomized, superiority trial on women undergoing IVF was conducted from April 2007 until February 2012 at the University Department of Gynaecological Endocrinology and Reproductive Medicine, Heidelberg, Germany.The study was powered to detect an 14% increase in the clinical pregnancy rate and two sequential tests were planned using the Pocock spending function. At the first interim analysis, 279 women had been randomly assigned to intrauterine diluted SP (20% SP in saline from the patients' partner) (n = 138) or placebo (n = 141) at the time of ovum pick-up.The clinical pregnancy rate per randomized patient was 37/138 (26.8%) in the SP group and 41/141 (29.1%) in the placebo group (difference: −2.3%, 95% confidence interval of the difference: −12.7 to +8.2%; P = 0.69). The live birth rate per randomized patient was 28/138 (20.3%) in the SP group and 33/141 (23.4%) in the placebo group (difference: −3.1%, 95% confidence interval of the difference: −12.7 to +6.6%; P = 0.56). It was decided to terminate the trial due to futility at the first interim analysis, at a conditional power of 62%.The confidence interval of the difference remains wide, thus clinically relevant differences cannot reliably be excluded based on this single study.The results of this study cast doubt on the validity of the concept that SP increases endometrial receptivity and thus implantation in humans.Funding was provided by the department's own research facilities.DRKS00004615.
DOI:doi:10.1093/humrep/det351
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/humrep/det351
 DOI: https://doi.org/10.1093/humrep/det351
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1770813721
Verknüpfungen:→ Zeitschrift

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