Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival

• Verfasst von: Vrieling, Alina [VerfasserIn]
• Verfasst von: Seibold, Petra Beate [VerfasserIn]
• Verfasst von: Johnson, Theron S. [VerfasserIn]
• Verfasst von: Heinz, Judith [VerfasserIn]
• Verfasst von: Obi, Nadia [VerfasserIn]
• Verfasst von: Kaaks, Rudolf [VerfasserIn]
• Verfasst von: Flesch-Janys, Dieter [VerfasserIn]
• Verfasst von: Chang-Claude, Jenny [VerfasserIn]
• Titel: Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival
• Titelzusatz: Influence of tumor characteristics and lifestyle factors?
• Verf.angabe: Alina Vrieling, Petra Seibold, Theron S. Johnson, Judith Heinz, Nadia Obi, Rudolf Kaaks, Dieter Flesch-Janys and Jenny Chang-Claude
• Jahr: 2014
• Umfang: 12 S.
• Teil: volume:134
• Teil: year:2014
• Teil: number:12
• Teil: pages:2972-2983
• Teil: extent:12
• Fussnoten: First published: 22 November 2013 ; Gesehen am 16.09.2021
• Titel Quelle: Enthalten in: International journal of cancer
• Ort Quelle: Bognor Regis : Wiley-Liss, 1966
• Jahr Quelle: 2014
• Band/Heft Quelle: 134(2014), 12, Seite 2972-2983
• ISSN Quelle: 1097-0215
• DOI: doi:10.1002/ijc.28628
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 25(OH)D
• Sach-SW: breast neoplasms
• Sach-SW: mortality
• Sach-SW: recurrence
• Sach-SW: vitamin D
• K10plus-PPN: 1770836640

Abstract

We previously reported that lower post-diagnostic circulating 25-hydroxyvitamin D [25(OH)D] concentrations were associated with higher risk of overall mortality and distant disease in stage I-IV postmenopausal breast cancer survivors. This association was now re-examined in an extended dataset to investigate potential effect modification by tumor characteristics and lifestyle factors. A prospective cohort study was conducted in Germany including 2,177 incident stage I-IV postmenopausal breast cancer patients aged 50-74 years. Patients were diagnosed between 2001 and 2005 and median follow-up time was 5.3 years. Cox proportional hazards models were stratified by age at diagnosis, study center and season of blood collection and adjusted for other prognostic factors. A meta-analysis of studies on circulating 25(OH)D and mortality in breast cancer patients was performed to summarize evidence. Lower concentrations of 25(OH)D were significantly associated with higher risk of overall mortality [hazard ratio (HR) lowest vs. highest tertile = 1.86; 95% confidence interval (CI): 1.22, 2.82; p-trend = 0.002] and distant disease (HR = 1.76; 95% CI: 1.24, 2.49; p-trend = 0.003) in stage I-IIIa but not in stage IIIb-IV breast cancer patients. No significant interaction by lifestyle factors was observed (all p-interaction > 0.05). The meta-analysis yielded significant associations with overall and breast cancer-specific mortality (lowest vs. highest quantile: HR = 1.52; 95% CI: 1.22, 1.88 and HR = 1.74; 95% CI: 1.23, 2.40, respectively). In conclusion, post-diagnostic circulating 25(OH)D concentrations were associated with overall mortality and distant disease in stage I-IIIa postmenopausal breast cancer patients. This association was not strongly modified by lifestyle factors.