| |  Online-Ressource |
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| Verfasst von: | Kamel, Wael [VerfasserIn]  |
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| | Noerenberg, Marko [VerfasserIn] |
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| | Cerikan, Berati [VerfasserIn] |
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| | Chen, Honglin [VerfasserIn] |
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| | Järvelin, Aino I. [VerfasserIn] |
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| | Kammoun, Mohamed [VerfasserIn] |
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| | Lee, Jeffrey Y. [VerfasserIn] |
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| | Shuai, Ni [VerfasserIn] |
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| | Garcia-Moreno, Manuel [VerfasserIn] |
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| | Andrejeva, Anna [VerfasserIn] |
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| | Deery, Michael J. [VerfasserIn] |
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| | Johnson, Natasha [VerfasserIn] |
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| | Neufeldt, Christopher [VerfasserIn] |
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| | Cortese, Mirko [VerfasserIn] |
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| | Knight, Michael L. [VerfasserIn] |
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| | Lilley, Kathryn S. [VerfasserIn] |
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| | Martinez, Javier [VerfasserIn] |
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| | Davis, Ilan [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Mohammed, Shabaz [VerfasserIn] |
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| | Castello, Alfredo [VerfasserIn] |
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| Titel: | Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection |
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| Verf.angabe: | Wael Kamel, Marko Noerenberg, Berati Cerikan, Honglin Chen, Aino I. Järvelin, Mohamed Kammoun, Jeffrey Y. Lee, Ni Shuai, Manuel Garcia-Moreno, Anna Andrejeva, Michael J. Deery, Natasha Johnson, Christopher J. Neufeldt, Mirko Cortese, Michael L. Knight, Kathryn S. Lilley, Javier Martinez, Ilan Davis, Ralf Bartenschlager, Shabaz Mohammed, and Alfredo Castello |
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| E-Jahr: | 2021 |
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| Jahr: | 1 July 2021 |
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| Umfang: | 24 S. |
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| Fussnoten: | Online veröffentlicht am 24. Mai 2021 ; Gesehen am 22.09.2021 |
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| Titel Quelle: | Enthalten in: Molecular cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1997 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 81(2021), 13 vom: Juli, Seite 2851-2867, e1-e7 |
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| ISSN Quelle: | 1097-4164 |
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| Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a multi-omic approach to identify systematically and comprehensively the cellular and viral RBPs that are involved in SARS-CoV-2 infection. We reveal that SARS-CoV-2 infection profoundly remodels the cellular RNA-bound proteome, which includes wide-ranging effects on RNA metabolic pathways, non-canonical RBPs, and antiviral factors. Moreover, we apply a new method to identify the proteins that directly interact with viral RNA, uncovering dozens of cellular RBPs and six viral proteins. Among them are several components of the tRNA ligase complex, which we show regulate SARS-CoV-2 infection. Furthermore, we discover that available drugs targeting host RBPs that interact with SARS-CoV-2 RNA inhibit infection. Collectively, our results uncover a new universe of host-virus interactions with potential for new antiviral therapies against COVID-19. |
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| DOI: | doi:10.1016/j.molcel.2021.05.023 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.molcel.2021.05.023 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S109727652100407X |
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| | DOI: https://doi.org/10.1016/j.molcel.2021.05.023 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antivirals |
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| | COVID-19 |
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| | host-virus interactions |
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| | HSP90 |
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| | ribonucleoprotein |
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| | RNA |
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| | RNA interactome |
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| | RNA-binding protein |
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| | SARS-CoV-2 |
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| | tRNA ligase |
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| | viral replication |
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| K10plus-PPN: | 1771607734 |
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| Verknüpfungen: | → Zeitschrift |
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Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection / Kamel, Wael [VerfasserIn]; 1 July 2021 (Online-Ressource)
