| Online-Ressource |
Verfasst von: | Lalwani, Pritesh Jaychand [VerfasserIn]  |
| Raftery, Martin J. [VerfasserIn]  |
| Kobak, Lidija [VerfasserIn]  |
| Rang, Andreas [VerfasserIn]  |
| Giese, Thomas [VerfasserIn]  |
| Matthaei, Markus [VerfasserIn]  |
| van den Elsen, Peter J. [VerfasserIn]  |
| Wolff, Thorsten [VerfasserIn]  |
| Krüger, Detlev H. [VerfasserIn]  |
| Schönrich, Günther [VerfasserIn]  |
Titel: | Hantaviral mechanisms driving HLA class I antigen presentation require both RIG-I and TRIF |
Verf.angabe: | Pritesh Lalwani, Martin J. Raftery, Lidija Kobak, Andreas Rang, Thomas Giese, Markus Matthaei, Peter J. van den Elsen, Thorsten Wolff, Detlev H. Krüger and Günther Schönrich |
E-Jahr: | 2013 |
Jahr: | 4/7/2013 |
Umfang: | 11 S. |
Teil: | volume:43 |
| year:2013 |
| number:10 |
| month:10 |
| pages:2566-2576 |
| extent:11 |
Fussnoten: | Gesehen am 22.09.2021 |
Titel Quelle: | Enthalten in: European journal of immunology |
Ort Quelle: | Weinheim : Wiley-VCH, 1971 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 43(2013), 10 vom: Okt., Seite 2566-2576 |
ISSN Quelle: | 1521-4141 |
Abstract: | Hantaviruses are emerging human pathogens. They induce an unusually strong antiviral response of human HLA class I (HLA-I) restricted CD8+ T cells that may contribute to tissue damage and hantavirus-associated disease. In this study, we analyzed possible hantaviral mechanisms that enhance the HLA-I antigen presentation machinery. Upon hantavirus infection of various human and primate cell lines, we observed transactivation of promoters controlling classical HLA molecules. Hantavirus-induced HLA-I upregulation required proteasomal activity and was associated with increased TAP expression. Intriguingly, human DCs acquired the capacity to cross-present antigen upon hantavirus infection. Furthermore, knockdown of TIR domain containing adaptor inducing IFN-β or retinoic acid inducible gene I abolished hantavirus-driven HLA-I induction. In contrast, MyD88-dependent viral sensors were not involved in HLA-I induction. Our results show that hantaviruses strongly boost the HLA-I antigen presentation machinery by mechanisms that are dependent on both retinoic acid inducible gene I and TIR domain containing adaptor inducing IFN-β. |
DOI: | doi:10.1002/eji.201243066 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/eji.201243066 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201243066 |
| DOI: https://doi.org/10.1002/eji.201243066 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Antigen presentation/processing |
| Cross-presentation/priming |
| Immunopathology |
| Infectious diseases |
| Innate immunity |
K10plus-PPN: | 1771611367 |
Verknüpfungen: | → Zeitschrift |
Hantaviral mechanisms driving HLA class I antigen presentation require both RIG-I and TRIF / Lalwani, Pritesh Jaychand [VerfasserIn]; 4/7/2013 (Online-Ressource)