Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Hoppe, Simon Oliver [VerfasserIn]  |
|---|
| | Uzunoğlu, Gamze [VerfasserIn] |
|---|
| | Nussbaum-Krammer, Carmen [VerfasserIn] |
|---|
| Titel: | α-synuclein strains: Does amyloid conformation explain the heterogeneity of synucleinopathies? |
|---|
| Verf.angabe: | Simon Oliver Hoppe, Gamze Uzunoğlu and Carmen Nussbaum-Krammer |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 23 June 2021 |
|---|
| Umfang: | 20 S. |
|---|
| Teil: | volume:11 |
|---|
| | year:2021 |
|---|
| | number:7 |
|---|
| | supplement:special issue |
|---|
| | elocationid:931 |
|---|
| | pages:1-20 |
|---|
| | extent:20 |
|---|
| Fussnoten: | Gesehen am 22.09.2021 |
|---|
| Titel Quelle: | Enthalten in: Biomolecules |
|---|
| Ort Quelle: | Basel : MDPI, 2011 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 11(2021), 7, special issue, Artikel-ID 931, Seite 1-20 |
|---|
| ISSN Quelle: | 2218-273X |
|---|
| Abstract: | Synucleinopathies are a heterogeneous group of neurodegenerative diseases with amyloid deposits that contain the α-synuclein (SNCA/α-Syn) protein as a common hallmark. It is astonishing that aggregates of a single protein are able to give rise to a whole range of different disease manifestations. The prion strain hypothesis offers a possible explanation for this conundrum. According to this hypothesis, a single protein sequence is able to misfold into distinct amyloid structures that can cause different pathologies. In fact, a growing body of evidence suggests that conformationally distinct α-Syn assemblies might be the causative agents behind different synucleinopathies. In this review, we provide an overview of research on the strain hypothesis as it applies to synucleinopathies and discuss the potential implications for diagnostic and therapeutic purposes. |
|---|
| DOI: | doi:10.3390/biom11070931 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/biom11070931 |
|---|
| | Volltext: https://www.mdpi.com/2218-273X/11/7/931 |
|---|
| | DOI: https://doi.org/10.3390/biom11070931 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | alpha-synuclein |
|---|
| | amyloid |
|---|
| | conformational strains |
|---|
| | prion-like propagation |
|---|
| | prions |
|---|
| | synucleinopathies |
|---|
| K10plus-PPN: | 1771635975 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
α-synuclein strains: Does amyloid conformation explain the heterogeneity of synucleinopathies? / Hoppe, Simon Oliver [VerfasserIn]; 23 June 2021 (Online-Ressource)
68782379
