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Verfasst von:Seeßle, Jessica [VerfasserIn]   i
 Wenz, Theresa [VerfasserIn]   i
 Schnitzler, Paul [VerfasserIn]   i
 Gsenger, Julia [VerfasserIn]   i
 Giese, Thomas [VerfasserIn]   i
 Merle, Uta [VerfasserIn]   i
Titel:High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients
Titelzusatz:immunological findings
Verf.angabe:Jessica Seeßle, Theresa Hippchen, Paul Schnitzler, Julia Gsenger, Thomas Giese, Uta Merle
E-Jahr:2021
Jahr:July 1, 2021
Umfang:13 S.
Fussnoten:Gesehen am 23.09.2021
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2021
Band/Heft Quelle:16(2021), 7, Artikel-ID e0254129, Seite 1-13
ISSN Quelle:1932-6203
Abstract:SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome with the need of invasive ventilation. Pulmonary herpes simplex-1 (HSV-1) reactivation in invasively ventilated patients is a known phenomenon. To date very little is known about the frequency and the predisposing factors of HSV-1 reactivation in COVID-19. Therefore, we evaluated our cohort of invasively ventilated COVID-19 patients with severe pneumonia for HSV-1 in respiratory specimens and combined these results with functional immunomonitoring of the peripheral blood. Tracheal secretions and bronchial lavages were screened by PCR for HSV-1 positivity. Comprehensive immunophenotyping and quantitative gene expression analysis of Interferon-stimulated genes (IFI44L, MX1, RSAD2, ISIG15 and IFIT1) and IL-1 beta were performed in whole blood. Time course of infection beginning at symptom onset was grouped into three phases (“early” phase 1: day 1-10, “middle” phase 2: day 11-30 and “late” phase 3: day 31-40). Pulmonary HSV-1 reactivation was exclusively observed in the later phases 2 and 3 in 15 of 18 analyzed patients. By FACS analysis a significant increase in activated CD8 T cells (CD38+HLADR+) in phase 2 was found when compared with phase 1 (p<0.05). Expression of Interferon-stimulated genes (IFI44L, RSAD2 ISIG15, MX1, IFIT1) was significantly lower after HSV-1 detection than before. Taken together, reactivation of HSV-1 in the later phase of SARS-CoV-2- infection occurs in parallel with a drop of antiviral innate responsiveness as shown by decreased expression of Interferon-stimulated genes and a concurrent increase of highly activated CD38+HLADR+ CD8 T cells.
DOI:doi:10.1371/journal.pone.0254129
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pone.0254129
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254129
 DOI: https://doi.org/10.1371/journal.pone.0254129
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Blood
 COVID 19
 Cytotoxic T cells
 Genetic interference
 Interferons
 Respiratory infections
 SARS CoV 2
 Secretion
K10plus-PPN:1771742046
Verknüpfungen:→ Zeitschrift

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