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| Verfasst von: | Nůsková, Hana [VerfasserIn]  |
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| | Serebryakova, Marina V. [VerfasserIn] |
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| | Ferrer-Caelles, Anna [VerfasserIn] |
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| | Sachsenheimer, Timo [VerfasserIn] |
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| | Lüchtenborg, Christian [VerfasserIn] |
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| | Miller, Aubry K. [VerfasserIn] |
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| | Brügger, Britta [VerfasserIn] |
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| | Kordyukova, Larisa V. [VerfasserIn] |
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| | Teleman, Aurelio A. [VerfasserIn] |
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| Titel: | Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins |
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| Verf.angabe: | Hana Nůsková, Marina V. Serebryakova, Anna Ferrer-Caelles, Timo Sachsenheimer, Christian Lüchtenborg, Aubry K. Miller, Britta Brügger, Larisa V. Kordyukova & Aurelio A. Teleman |
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| E-Jahr: | 2021 |
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| Jahr: | 28 July 2021 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 26.09.2021 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 4590, Seite 1-15 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Abstract - Covalent attachment of C16:0 to proteins (palmitoylation) regulates protein function. Proteins are also S-acylated by other fatty acids including C18:0. Whether protein acylation with different fatty acids has different functional outcomes is not well studied. We show here that C18:0 (stearate) and C18:1 (oleate) compete with C16:0 to S-acylate Cys3 of GNAI proteins. C18:0 becomes desaturated so that C18:0 and C18:1 both cause S-oleoylation of GNAI. Exposure of cells to C16:0 or C18:0 shifts GNAI acylation towards palmitoylation or oleoylation, respectively. Oleoylation causes GNAI proteins to shift out of cell membrane detergent-resistant fractions where they potentiate EGFR signaling. Consequently, exposure of cells to C18:0 reduces recruitment of Gab1 to EGFR and reduces AKT activation. This provides a molecular mechanism for the anti-tumor effects of C18:0, uncovers a mechanistic link how metabolites affect cell signaling, and provides evidence that the identity of the fatty acid acylating a protein can have functional consequences. |
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| DOI: | doi:10.1038/s41467-021-24844-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-021-24844-9 |
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| | Volltext: http://www.nature.com/articles/s41467-021-24844-9 |
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| | DOI: https://doi.org/10.1038/s41467-021-24844-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1771804564 |
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| Verknüpfungen: | → Zeitschrift |
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Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins / Nůsková, Hana [VerfasserIn]; 28 July 2021 (Online-Ressource)
