Role of the nuclear receptor Tailless in adult neural stem cells

• Verfasst von: Wang, Yu [VerfasserIn]
• Verfasst von: Liu, Hai-Kun [VerfasserIn]
• Verfasst von: Schütz, Günther [VerfasserIn]
• Titel: Role of the nuclear receptor Tailless in adult neural stem cells
• Verf.angabe: Yu Wang, Hai-Kun Liu, Günther Schütz
• E-Jahr: 2013
• Jahr: 13 February 2013
• Umfang: 3 S.
• Fussnoten: Gesehen am 30.09.2021
• Titel Quelle: Enthalten in: Mechanisms of development
• Ort Quelle: Shannon : Elsevier, 1990
• Jahr Quelle: 2013
• Band/Heft Quelle: 130(2013), 6, Seite 388-390
• ISSN Quelle: 1872-6356
• DOI: doi:10.1016/j.mod.2013.02.001
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Neural stem cells
• Sach-SW: Neurogenesis
• Sach-SW: Subgranular zone
• Sach-SW: Subventricular zone
• Sach-SW: Tailless (Tlx)
• K10plus-PPN: 1772133841

Abstract

Tailless (Tlx) is an orphan nuclear receptor which is specifically expressed in the neural stem cells of the two largest germinal neurogenesis zones in the adult mouse brain, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus. By interacting with its cofactors, Tlx represses its target genes and plays an important role in the maintenance of adult NSCs. This review provides a snapshot of current knowledge about Tlx function in adult NSCs.