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Verfasst von:Szyc, Łukasz [VerfasserIn]   i
 Scharlach, Constantin [VerfasserIn]   i
 Hänßle, Holger [VerfasserIn]   i
 Müller-Christmann, Christine [VerfasserIn]   i
Titel:In vivo two-photon-excited cellular fluorescence of melanin, NAD(P)H, and keratin enables an accurate differential diagnosis of seborrheic keratosis and pigmented cutaneous melanoma
Verf.angabe:Lukasz Szyc, Constantin Scharlach, Holger Haenssle, and Christine Fink
E-Jahr:2021
Jahr:Jul. 14, 2021
Umfang:9 S.
Fussnoten:Gesehen am 30.09.2021
Titel Quelle:Enthalten in: Journal of biomedical optics
Ort Quelle:Bellingham, Wash. : SPIE, 1996
Jahr Quelle:2021
Band/Heft Quelle:26(2021), 7, Seite i075002$p1-9
ISSN Quelle:1560-2281
Abstract:Significance: Seborrheic keratoses (SKs) are harmless pigmented skin lesions (PSLs) that may be confused clinically not only with other benign conditions but also with cutaneous melanoma (CM). As SKs are one of the most common neoplasms in adults, the importance of their correct diagnosis is high. Misclassifying SK as malignant is not rare and leads to a high number of unnecessary biopsies. On the other hand, misdiagnosing CM as SK may have a large impact on prognosis or therapy. Aim: In the non-invasive technique of dermatofluoroscopy, the fluorophores in melanocytes and keratinocytes are excited in vivo with nanosecond laser pulses and the resulting spectrally resolved, melanin-dominated fluorescence signals are used to differentiate between pigmented benign lesions and CM. Approach: In this single-center, non-interventional study, 33 PSLs of 20 patients were scanned with dermatofluoroscopy in vivo. For all included cases, dermatofluoroscopic signals were compared to pathology classification. Results: The characteristic spectral features of SK were identified, where the signals are dominated by keratin, NAD(P)H, and melanin. The fluorescence spectra of SKs differed substantially from those of CM: a characteristic spectrum of SK has been identified in 27 of 28 SKs. Conclusions: The high-accuracy differential diagnosis between CM and SK is possible with dermatofluoroscopy.
DOI:doi:10.1117/1.JBO.26.7.075002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1117/1.JBO.26.7.075002
 Volltext: https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-7/075002/In-vivo-two-photon-exc ...
 DOI: https://doi.org/10.1117/1.JBO.26.7.075002
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1772160849
Verknüpfungen:→ Zeitschrift

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