Le virus de la fièvre de la vallée du Rift et son étonnante protéine NSs

• Verfasst von: Léger, Psylvia [VerfasserIn]
• Verfasst von: Lozach, Pierre-Yves [VerfasserIn]
• Titel: Le virus de la fièvre de la vallée du Rift et son étonnante protéine NSs
• Paralleltitel: Rift Valley fever virus and the amazing NSs protein
• Verf.angabe: Psylvia Leger, Pierre-Yves Lozach
• E-Jahr: 2021
• Jahr: 28 June 2021
• Umfang: 8 S.
• Teil: volume:37
• Teil: year:2021
• Teil: number:6/7
• Teil: pages:601-608
• Teil: extent:8
• Fussnoten: Gesehen am 01.10.2021
• Titel Quelle: Enthalten in: Médecine sciences
• Ort Quelle: Paris : EDK, Editions Médicales et Scientifiques, 2001
• Jahr Quelle: 2021
• Band/Heft Quelle: 37(2021), 6/7, Seite 601-608
• ISSN Quelle: 1958-5381
• DOI: doi:10.1051/medsci/2021090
• Datenträger: Online-Ressource
• Sprache: fre
• Sach-SW: bunyaviruses
• Sach-SW: dc-sign
• Sach-SW: entry
• Sach-SW: host
• Sach-SW: receptor
• Sach-SW: replication
• Sach-SW: reveals
• Sach-SW: transmission
• K10plus-PPN: 1772198013

Abstract

Rift Valley Fever Virus (RVFV) is an emerging zoonotic pathogen transmitted to humans and livestock through mosquito bites, which was first isolated in Kenya in 1930. The virus is classified by the WHO among the pathogens for which there is an urgent need to develop research, diagnostics, and therapies. However, the efforts developed to control the virus remain limited, and the virus is not well characterized. In this article, we will introduce RVFV and then focus on its virulence factor, the nonstructural protein NSs. We will mainly discuss the ability of this viral protein to form amyloid-like fibrils and its implication in the neurotoxicity associated with RVFV infection.