Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study

• Verfasst von: Krüchten, Ricarda von [VerfasserIn]
• Verfasst von: Lorbeer, Roberto [VerfasserIn]
• Verfasst von: Schuppert, Christopher [VerfasserIn]
• Verfasst von: Storz, Corinna [VerfasserIn]
• Verfasst von: Mujaj, Blerim [VerfasserIn]
• Verfasst von: Schulz, Holger [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Peters, Annette [VerfasserIn]
• Verfasst von: Bamberg, Fabian [VerfasserIn]
• Verfasst von: Karrasch, Stefan [VerfasserIn]
• Verfasst von: Schlett, Christopher L. [VerfasserIn]
• Titel: Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study
• Verf.angabe: Ricarda von Krüchten, Roberto Lorbeer, Christopher Schuppert, Corinna Storz, Blerim Mujaj, Holger Schulz, Hans-Ulrich Kauczor, Annette Peters, Fabian Bamberg, Stefan Karrasch & Christopher L. Schlett
• E-Jahr: 2021
• Jahr: 09 August 2021
• Umfang: 9 S.
• Fussnoten: Gesehen am 02.10.2021
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Springer Nature, 2011
• Jahr Quelle: 2021
• Band/Heft Quelle: 11(2021), Artikel-ID 16173, Seite 1-9
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-021-95655-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1772233021

Abstract

To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.