| |  Online-Ressource |
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| Verfasst von: | Benning, Louise [VerfasserIn]  |
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| | Töllner, Maximilian [VerfasserIn] |
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| | Hidmark, Asa S. [VerfasserIn] |
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| | Schaier, Matthias [VerfasserIn] |
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| | Nußhag, Christian [VerfasserIn] |
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| | Kälble, Florian [VerfasserIn] |
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| | Reichel, Paula [VerfasserIn] |
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| | Buylaert, Mirabel [VerfasserIn] |
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| | Grenz, Julia [VerfasserIn] |
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| | Ponath, Gerald [VerfasserIn] |
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| | Klein, Katrin [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Süsal, Caner [VerfasserIn] |
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| | Schnitzler, Paul [VerfasserIn] |
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| | Morath, Christian [VerfasserIn] |
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| | Speer, Claudius [VerfasserIn] |
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| Titel: | Heterologous ChAdOx1 nCoV-19/BNT162b2 prime-boost vaccination induces strong humoral responses among health care workers |
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| Verf.angabe: | Louise Benning, Maximilian Töllner, Asa Hidmark, Matthias Schaier, Christian Nusshag, Florian Kälble, Paula Reichel, Mirabel Buylaert, Julia Grenz, Gerald Ponath, Katrin Klein, Martin Zeier, Caner Süsal, Paul Schnitzler, Christian Morath and Claudius Speer |
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| E-Jahr: | 2021 |
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| Jahr: | 4 August 2021 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 06.10.2021 |
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| Titel Quelle: | Enthalten in: Vaccines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 9(2021), 8, Artikel-ID 857, Seite 1-13 |
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| ISSN Quelle: | 2076-393X |
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| Abstract: | Despite limited data on safety and immunogenicity, heterologous prime-boost vaccination is currently recommended for individuals with ChAdOx1 nCoV-19 prime immunization in certain age groups. In this prospective, single-center study we included 166 health care workers from Heidelberg University Hospital who received either heterologous ChAdOx1 nCoV-19/BNT162b2, homologous BNT162b2 or homologous ChAdOx1 nCoV-19 vaccination between December 2020 and May 2021. We measured anti-S1 IgG, SARS-CoV-2 specific neutralizing antibodies, and antibodies against different SARS-CoV-2 fragments 0-3 days before and 19-21 days after boost vaccination. Before boost, 55/70 (79%) ChAdOx1 nCoV-19-primed compared with 44/45 (98%) BNT162b2-primed individuals showed positive anti-S1 IgG with a median (IQR) anti-S1 IgG index of 1.95 (1.05-2.99) compared to 9.38 (6.26-17.12). SARS-CoV-2 neutralizing antibodies exceeded the threshold in 24/70 (34%) of ChAdOx1 nCoV-19-primed and 43/45 (96%) of BNT162b2-primed individuals. After boosting dose, median (IQR) anti-S1 IgG index in heterologous ChAdOx1 nCoV-19/BNT162b2 vaccinees was 116.2 (61.84-170), compared to 13.09 (7.03-29.02) in homologous ChAdOx1 nCoV-19 and 145.5 (100-291.1) in homologous BNT162b2 vaccinees. All boosted vaccinees exceeded the threshold for neutralization, irrespective of their vaccination scheme. Vaccination was well-tolerated overall. We show that heterologous ChAdOx1 nCoV-19/BNT162b2 vaccination is safe and induces a strong and broad humoral response in healthy individuals. |
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| DOI: | doi:10.3390/vaccines9080857 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/vaccines9080857 |
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| | Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.3390%2Fvaccine ... |
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| | DOI: https://doi.org/10.3390/vaccines9080857 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adenovirus-vectored vaccine |
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| | BNT162b2 |
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| | ChAdOx1 nCoV-19 |
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| | covid-19 |
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| | COVID-19 vaccination |
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| | heterologous vaccination |
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| | humoral response |
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| | mRNA vaccine |
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| | SARS-CoV-2 |
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| K10plus-PPN: | 1772557382 |
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| Verknüpfungen: | → Zeitschrift |
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Heterologous ChAdOx1 nCoV-19/BNT162b2 prime-boost vaccination induces strong humoral responses among health care workers / Benning, Louise [VerfasserIn]; 4 August 2021 (Online-Ressource)
