| |  Online-Ressource |
|---|
| Verfasst von: | Ivanov, Iliyan [VerfasserIn]  |
|---|
| | Parvaz, Muhammad A. [VerfasserIn] |
|---|
| | Velthorst, Eva [VerfasserIn] |
|---|
| | Shaik, Riaz B. [VerfasserIn] |
|---|
| | Sandin, Sven [VerfasserIn] |
|---|
| | Gan, Gabriela [VerfasserIn] |
|---|
| | Spechler, Philip [VerfasserIn] |
|---|
| | Albaugh, Matthew [VerfasserIn] |
|---|
| | Chaarani, Bader [VerfasserIn] |
|---|
| | Mackey, Scott [VerfasserIn] |
|---|
| | Banaschewski, Tobias [VerfasserIn] |
|---|
| | Bokde, Arun L. W. [VerfasserIn] |
|---|
| | Bromberg, Uli [VerfasserIn] |
|---|
| | Büchel, Christian [VerfasserIn] |
|---|
| | Quinlan, Erin Burke [VerfasserIn] |
|---|
| | Desrivières, Sylvane [VerfasserIn] |
|---|
| | Flor, Herta [VerfasserIn] |
|---|
| | Grigis, Antoine [VerfasserIn] |
|---|
| | Gowland, Penny [VerfasserIn] |
|---|
| | Heinz, Andreas [VerfasserIn] |
|---|
| | Ittermann, Bernd [VerfasserIn] |
|---|
| | Martinot, Jean-Luc [VerfasserIn] |
|---|
| | Paillère Martinot, Marie-Laure [VerfasserIn] |
|---|
| | Artiges, Eric [VerfasserIn] |
|---|
| | Lemaitre, Herve [VerfasserIn] |
|---|
| | Nees, Frauke [VerfasserIn] |
|---|
| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
|---|
| | Paus, Tomáš [VerfasserIn] |
|---|
| | Poustka, Luise [VerfasserIn] |
|---|
| | Hohmann, Sarah [VerfasserIn] |
|---|
| | Millenet, Sabina [VerfasserIn] |
|---|
| | Fröhner, Juliane H. [VerfasserIn] |
|---|
| | Smolka, Michael N. [VerfasserIn] |
|---|
| | Walter, Henrik [VerfasserIn] |
|---|
| | Whelan, Robert [VerfasserIn] |
|---|
| | Schumann, Gunter [VerfasserIn] |
|---|
| | Garavan, Hugh [VerfasserIn] |
|---|
| Titel: | Substance use initiation, particularly alcohol, in drug-naive adolescents |
|---|
| Titelzusatz: | possible predictors and consequences from a large cohort naturalistic study |
|---|
| Verf.angabe: | Iliyan Ivanov, Muhammad A. Parvaz, Eva Velthorst, Riaz B. Shaik, Sven Sandin, Gabriela Gan, Philip Spechler, Matthew D. Albaugh, Bader Chaarani, Scott Mackey, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Herve Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | May 2021 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 06.10.2021 |
|---|
| Titel Quelle: | Enthalten in: American Academy of Child and Adolescent PsychiatryJournal of the American Academy of Child and Adolescent Psychiatry |
|---|
| Ort Quelle: | Kidlington [u.a.] : Elsevier, 1987 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 60(2021), 5 vom: Mai, Seite 623-636 |
|---|
| ISSN Quelle: | 1527-5418 |
|---|
| Abstract: | Objective - It is unclear whether deviations in brain and behavioral development, which may underpin elevated substance use during adolescence, are predispositions for or consequences of substance use initiation. Here, we examine behavioral and neuroimaging indices at early and mid-adolescence in drug-naive youths to identify possible predisposing factors for substance use initiation and its possible consequences. - Method - Among 304 drug-naive adolescents at baseline (age 14 years) from the IMAGEN dataset, 83 stayed drug-naive, 133 used alcohol on 1 to 9 occasions, 42 on 10 to 19 occasions, 27 on 20 to 39 occasions, and 19 on >40 occasions at follow-up (age 16 years). Baseline measures included brain activation during the Monetary Incentive Delay task. Data at both baseline and follow-up included measures of trait impulsivity and delay discounting. - Results - From baseline to follow-up, impulsivity decreased in the 0 and 1- to 9-occasions groups (p < .004), did not change in the 10- to 19-occasions and 20- to 29-occasions groups (p > .294), and uncharacteristically increased in the >40-occasions group (p = .046). Furthermore, blunted medial orbitofrontal cortex activation during reward outcome at baseline significantly predicted higher alcohol use frequency at follow-up, above and beyond behavioral and clinical variables (p = .008). - Conclusion - These results suggest that the transition from no use to frequent drinking in early to mid-adolescence may disrupt normative developmental changes in behavioral control. In addition, blunted activity of the medial orbitofrontal cortex during reward outcome may underscore a predisposition toward the development of more severe alcohol use in adolescents. This distinction is clinically important, as it informs early intervention efforts in preventing the onset of substance use disorder in adolescents. |
|---|
| DOI: | doi:10.1016/j.jaac.2020.08.443 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jaac.2020.08.443 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S0890856720319511 |
|---|
| | DOI: https://doi.org/10.1016/j.jaac.2020.08.443 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | adolescence |
|---|
| | alcohol use |
|---|
| | IMAGEN |
|---|
| | impulsivity |
|---|
| | reward processing |
|---|
| K10plus-PPN: | 1772591165 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Substance use initiation, particularly alcohol, in drug-naive adolescents / Ivanov, Iliyan [VerfasserIn]; May 2021 (Online-Ressource)
