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Verfasst von:Balint, Bettina [VerfasserIn]   i
 Bhatia, Kailash P. [VerfasserIn]   i
Titel:Autoimmune movement disorders with neuronal antibodies
Titelzusatz:an update
Verf.angabe:Bettina Balint, Kailash P. Bhatia
Jahr:2021
Umfang:7 S.
Fussnoten:Gesehen am 12.10.2021
Titel Quelle:Enthalten in: Current opinion in neurology
Ort Quelle:London : Lippincott Williams & Wilkins, 1993
Jahr Quelle:2021
Band/Heft Quelle:34(2021), 4, Seite 565-571
ISSN Quelle:1473-6551
Abstract:Purpose of review The rapid developments in neuroimmunology reflect also on the field of movement disorders, where there is an ever expanding spectrum of new antibodies. This review focuses on the new neuronal antibodies, their clinical spectrum and recent pathophysiological insights. It gives an update on previous work about neuronal antibody-related movement disorders. Recent findings Phosphodiesterase 10A antibodies are a new marker of paraneoplastic chorea. Seizure-related 6 homolog like 2 antibodies are a differential diagnosis in atypical parkinsonism with cerebellar ataxia and cognitive impairment. mGluR5-antibodies cause various hyperkinetic movement disorders with Ophelia syndrome. Most new antibodies were described in the context of cerebellar ataxia: Kelch-like protein 11 antibodies are a comparatively frequent marker of paraneoplastic cerebellar ataxia with germ cell tumours. Nonparaneoplastic cerebellar ataxia occurs with Septin-5 and neurochondrin antibodies. Studies into the mechanisms of neuronal surface antibodies have shown that there is much pathophysiological heterogeneity, ranging from immediate antagonistic effect to induction of neurodegeneration after weeks. The new markers of autoimmune movement disorders are key to identify those patients that may benefit from immunotherapy, and tumour therapy, where appropriate. Insights into the underlying pathophysiology might guide treatment decisions and help tailoring more targeted approaches in the future.
DOI:doi:10.1097/WCO.0000000000000956
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1097/WCO.0000000000000956
 Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1097%2 ...
 DOI: https://doi.org/10.1097/WCO.0000000000000956
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:antibodies
 ataxia
 autoimmune
 chorea
 clinical-features
 movement disorders
 pathophysiology
K10plus-PPN:1773337564
Verknüpfungen:→ Zeitschrift

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