Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Mease, Rebecca A. [VerfasserIn]   i
 Gonzalez, Antonio J. [VerfasserIn]   i
Titel:Corticothalamic pathways from layer 5
Titelzusatz:emerging roles in computation and pathology
Verf.angabe:Rebecca A. Mease and Antonio J. Gonzalez
E-Jahr:2021
Jahr:09 September 2021
Umfang:21 S.
Teil:volume:15
 year:2021
 day:9
 month:09
 elocationid:730211
 pages:1-21
 extent:21
Fussnoten:Gesehen am 12.10.2021
Titel Quelle:Enthalten in: Frontiers in neural circuits
Ort Quelle:Lausanne : Frontiers Research Foundation, 2007
Jahr Quelle:2021
Band/Heft Quelle:15(2021) vom: 9. Sept., Artikel-ID 730211, Seite 1-21
ISSN Quelle:1662-5110
Abstract:Large portions of the thalamus receive strong driving input from cortical layer 5 (L5) neurons but the role of this important pathway in cortical and thalamic computations is not well understood. L5-recipient “higher-order” thalamic regions participate in cortico-thalamo-cortical (CTC) circuits that are increasingly recognized to be (1) anatomically and functionally distinct from better-studied “first-order” CTC networks, and (2) integral to cortical activity related to learning and perception. Additionally, studies are beginning to elucidate the clinical relevance of these networks, as dysfunction across these pathways have been implicated in several pathological states. In this review, we highlight recent advances in understanding L5 CTC networks across sensory modalities and brain regions, particularly studies leveraging cell-type-specific tools that allow precise experimental access to L5 CTC circuits. We aim to provide a focused and accessible summary of the anatomical, physiological, and computational properties of L5-originating CTC networks, and outline their underappreciated contribution in pathology. We particularly seek to connect single-neuron and synaptic properties to network (dys)function and emerging theories of cortical computation, and highlight information processing in L5 CTC networks as a promising focus for computational studies.
DOI:doi:10.3389/fncir.2021.730211
URL:kostenfrei: Volltext ; Verlag: https://doi.org/10.3389/fncir.2021.730211
 kostenfrei: Volltext: https://www.frontiersin.org/article/10.3389/fncir.2021.730211
 DOI: https://doi.org/10.3389/fncir.2021.730211
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1773341030
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68788668   QR-Code
zum Seitenanfang