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Status: Bibliographieeintrag

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Verfasst von:Banan, Rouzbeh [VerfasserIn]   i
 Akbarian, Arash [VerfasserIn]   i
 Samii, Majid [VerfasserIn]   i
 Samii, Amir [VerfasserIn]   i
 Bertalanffy, Helmut [VerfasserIn]   i
 Lehmann, Ulrich [VerfasserIn]   i
 Hartmann, Christian [VerfasserIn]   i
 Brüning, Roland [VerfasserIn]   i
Titel:Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures
Verf.angabe:Rouzbeh Banan, Arash Akbarian, Majid Samii, Amir Samii, Helmut Bertalanffy, Ulrich Lehmann, Christian Hartmann, Roland Brüning
E-Jahr:2021
Jahr:August 4, 2021
Umfang:12 S.
Fussnoten:Gesehen am 13.10.2021
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2021
Band/Heft Quelle:16(2021), 8, Artikel-ID e0249647, Seite 1-12
ISSN Quelle:1932-6203
Abstract:Purpose The entity ‘diffuse midline glioma, H3 K27M-mutant (DMG)’ was introduced in the revised 4th edition of the 2016 WHO classification of brain tumors. However, there are only a few reports on magnetic resonance imaging (MRI) of these tumors. Thus, we conducted a retrospective survey focused on MRI features of DMG compared to midline glioblastomas H3 K27M-wildtype (mGBM-H3wt). Methods We identified 24 DMG cases and 19 mGBM-H3wt patients as controls. After being retrospectively evaluated for microscopic evidence of microvascular proliferations (MVP) and tumor necrosis by two experienced neuropathologists to identify the defining histological criteria of mGBM-H3wt, the samples were further analyzed by two experienced readers regarding imaging features such as shape, peritumoral edema and contrast enhancement. Results The DMG were found in the thalamus in 37.5% of cases (controls 63%), in the brainstem in 50% (vs. 32%) and spinal cord in 12.5% (vs. 5%). In MRI and considering MVP, DMG were found to be by far less likely to develop peritumoral edema (OR: 0.13; 95%-CL: 0.02-0.62) (p = 0.010). They, similarly, were associated with a significantly lower probability of developing strong contrast enhancement compared to mGBM-H3wt (OR: 0.10; 95%-CL: 0.02-0.47) (P = 0.003). Conclusion Despite having highly variable imaging features, DMG exhibited markedly less edema and lower contrast enhancement in MRI compared to mGBM-H3wt. Of these features, the enhancement level was associated with evidence of MVP.
DOI:doi:10.1371/journal.pone.0249647
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pone.0249647
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249647
 DOI: https://doi.org/10.1371/journal.pone.0249647
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Brainstem
 Cancers and neoplasms
 Edema
 Glioma
 Lesions
 Magnetic resonance imaging
 Malignant tumors
 Necrosis
K10plus-PPN:1773531220
Verknüpfungen:→ Zeitschrift

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