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| Verfasst von: | Banan, Rouzbeh [VerfasserIn]  |
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| | Akbarian, Arash [VerfasserIn] |
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| | Samii, Majid [VerfasserIn] |
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| | Samii, Amir [VerfasserIn] |
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| | Bertalanffy, Helmut [VerfasserIn] |
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| | Lehmann, Ulrich [VerfasserIn] |
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| | Hartmann, Christian [VerfasserIn] |
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| | Brüning, Roland [VerfasserIn] |
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| Titel: | Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures |
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| Verf.angabe: | Rouzbeh Banan, Arash Akbarian, Majid Samii, Amir Samii, Helmut Bertalanffy, Ulrich Lehmann, Christian Hartmann, Roland Brüning |
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| E-Jahr: | 2021 |
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| Jahr: | August 4, 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 13.10.2021 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 16(2021), 8, Artikel-ID e0249647, Seite 1-12 |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Purpose The entity ‘diffuse midline glioma, H3 K27M-mutant (DMG)’ was introduced in the revised 4th edition of the 2016 WHO classification of brain tumors. However, there are only a few reports on magnetic resonance imaging (MRI) of these tumors. Thus, we conducted a retrospective survey focused on MRI features of DMG compared to midline glioblastomas H3 K27M-wildtype (mGBM-H3wt). Methods We identified 24 DMG cases and 19 mGBM-H3wt patients as controls. After being retrospectively evaluated for microscopic evidence of microvascular proliferations (MVP) and tumor necrosis by two experienced neuropathologists to identify the defining histological criteria of mGBM-H3wt, the samples were further analyzed by two experienced readers regarding imaging features such as shape, peritumoral edema and contrast enhancement. Results The DMG were found in the thalamus in 37.5% of cases (controls 63%), in the brainstem in 50% (vs. 32%) and spinal cord in 12.5% (vs. 5%). In MRI and considering MVP, DMG were found to be by far less likely to develop peritumoral edema (OR: 0.13; 95%-CL: 0.02-0.62) (p = 0.010). They, similarly, were associated with a significantly lower probability of developing strong contrast enhancement compared to mGBM-H3wt (OR: 0.10; 95%-CL: 0.02-0.47) (P = 0.003). Conclusion Despite having highly variable imaging features, DMG exhibited markedly less edema and lower contrast enhancement in MRI compared to mGBM-H3wt. Of these features, the enhancement level was associated with evidence of MVP. |
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| DOI: | doi:10.1371/journal.pone.0249647 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1371/journal.pone.0249647 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249647 |
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| | DOI: https://doi.org/10.1371/journal.pone.0249647 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Brainstem |
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| | Cancers and neoplasms |
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| | Edema |
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| | Glioma |
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| | Lesions |
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| | Magnetic resonance imaging |
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| | Malignant tumors |
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| | Necrosis |
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| K10plus-PPN: | 1773531220 |
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| Verknüpfungen: | → Zeitschrift |
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Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures / Banan, Rouzbeh [VerfasserIn]; August 4, 2021 (Online-Ressource)
