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Verfasst von:Nissen, Christoffer B. [VerfasserIn]   i
 Sciascia, Savino [VerfasserIn]   i
 de Andrade, Danieli [VerfasserIn]   i
 Atsumi, Tatsuya [VerfasserIn]   i
 Bruce, Ian N [VerfasserIn]   i
 Cron, Randy Q [VerfasserIn]   i
 Hendricks, Oliver [VerfasserIn]   i
 Roccatello, Dario [VerfasserIn]   i
 Stach-Jablonski, Ksenija [VerfasserIn]   i
 Trunfio, Mattia [VerfasserIn]   i
 Vinet, Évelyne [VerfasserIn]   i
 Schreiber, Karen [VerfasserIn]   i
Titel:The role of antirheumatics in patients with COVID-19
Verf.angabe:Christoffer B Nissen, Savino Sciascia, Danieli de Andrade, Tatsuya Atsumi, Ian N Bruce, Randy Q Cron, Oliver Hendricks, Dario Roccatello, Ksenija Stach, Mattia Trunfio, Évelyne Vinet, Karen Schreiber
E-Jahr:2021
Jahr:March 30, 2021
Umfang:13 S.
Fussnoten:Gesehen am 13.10.2021
Titel Quelle:Enthalten in: The lancet. Rheumatology
Ort Quelle:Amsterdam : Elsevier, 2019
Jahr Quelle:2021
Band/Heft Quelle:3(2021), 6, Seite e447-e459
ISSN Quelle:2665-9913
Abstract:The COVID-19 pandemic has resulted in more than 2 million deaths globally. Two interconnected stages of disease are generally recognised; an initial viral stage and a subsequent immune response phase with the clinical characteristics of hyperinflammation associated with acute respiratory distress syndrome. Therefore, many immune modulators and immunosuppressive drugs, which are widely used in rheumatological practice, have been proposed as treatments for patients with moderate or severe COVID-19. In this Review, we provide an overview of what is currently known about the efficacy and safety of antirheumatic therapies for the treatment of patients with COVID-19. Dexamethasone has been shown to reduce COVID-19 related mortality, interleukin-6 inhibitors to reduce risk of cardiovascular or respiratory organ support, and baricitinib to reduce time to recovery in hospitalised patients requiring oxygen support. Further studies are needed to identify whether there is any role for glucocorticoids in patients with less severe COVID-19. Although evidence on the use of other antirheumatic drugs has suggested some benefits, results from adequately powered clinical trials are urgently needed. The heterogeneity in dosing and the absence of uniform inclusion criteria and defined stage of disease studied in many clinical trials have affected the conclusions and comparability of trial results. However, after the success of dexamethasone in proving the anti-inflammatory hypothesis, the next 12 months will undoubtedly bring further clarity about the clinical utility and optimal dose and timing of other anti-rheumatic drugs in the management of COVID-19.
DOI:doi:10.1016/S2665-9913(21)00062-X
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/S2665-9913(21)00062-X
 Volltext: https://www.sciencedirect.com/science/article/pii/S266599132100062X
 DOI: https://doi.org/10.1016/S2665-9913(21)00062-X
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1773577557
Verknüpfungen:→ Zeitschrift

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