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Verfasst von:Quattrone, Diego [VerfasserIn]   i
 Ferraro, Laura [VerfasserIn]   i
 Tripoli, Giada [VerfasserIn]   i
 Cascia, Caterina La [VerfasserIn]   i
 Quigley, Harriet [VerfasserIn]   i
 Quattrone, Andrea [VerfasserIn]   i
 Jongsma, Hannah E. [VerfasserIn]   i
 Peschio, Simona Del [VerfasserIn]   i
 Gatto, Giusy [VerfasserIn]   i
 Group, Eu-Gei [VerfasserIn]   i
 Gayer-Anderson, Charlotte [VerfasserIn]   i
 Jones, Peter B. [VerfasserIn]   i
 Kirkbride, James B. [VerfasserIn]   i
 Barbera, Daniele La [VerfasserIn]   i
 Tarricone, Ilaria [VerfasserIn]   i
 Berardi, Domenico [VerfasserIn]   i
 Tosato, Sarah [VerfasserIn]   i
 Lasalvia, Antonio [VerfasserIn]   i
 Szöke, Andrei [VerfasserIn]   i
 Arango, Celso [VerfasserIn]   i
 Bernardo, Miquel [VerfasserIn]   i
 Bobes, Julio [VerfasserIn]   i
 Ben, Cristina Marta Del [VerfasserIn]   i
 Menezes, Paulo Rossi [VerfasserIn]   i
 Llorca, Pierre-Michel [VerfasserIn]   i
 Santos, Jose Luis [VerfasserIn]   i
 Sanjuán, Julio [VerfasserIn]   i
 Tortelli, Andrea [VerfasserIn]   i
 Velthorst, Eva [VerfasserIn]   i
 Haan, Lieuwe de [VerfasserIn]   i
 Rutten, Bart P. F. [VerfasserIn]   i
 Lynskey, Michael T. [VerfasserIn]   i
 Freeman, Tom P. [VerfasserIn]   i
 Sham, Pak C. [VerfasserIn]   i
 Cardno, Alastair G. [VerfasserIn]   i
 Vassos, Evangelos [VerfasserIn]   i
 Os, Jim van [VerfasserIn]   i
 Morgan, Craig [VerfasserIn]   i
 Reininghaus, Ulrich [VerfasserIn]   i
 Lewis, Cathryn M. [VerfasserIn]   i
 Murray, Robin M. [VerfasserIn]   i
 Forti, Marta Di [VerfasserIn]   i
Titel:Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients
Titelzusatz:the EU-GEI case-control study
Verf.angabe:Diego Quattrone, Laura Ferraro, Giada Tripoli, Caterina La Cascia, Harriet Quigley, Andrea Quattrone, Hannah E. Jongsma, Simona Del Peschio, Giusy Gatto, Eu-Gei Group, Charlotte Gayer-Anderson, Peter B. Jones, James B. Kirkbride, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Sarah Tosato, Antonio Lasalvia, Andrei Szöke, Celso Arango, Miquel Bernardo, Julio Bobes, Cristina Marta Del Ben, Paulo Rossi Menezes, Pierre-Michel Llorca, Jose Luis Santos, Julio Sanjuán, Andrea Tortelli, Eva Velthorst, Lieuwe de Haan, Bart P.F. Rutten, Michael T. Lynskey, Tom P. Freeman, Pak C. Sham, Alastair G. Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Ulrich Reininghaus, Cathryn M. Lewis, Robin M. Murray, Marta Di Forti
Jahr:2021
Umfang:9 S.
Fussnoten:Gesehen am 14.10.2021 ; First published online: 18 March 2020
Titel Quelle:Enthalten in: Psychological medicine
Ort Quelle:Cambridge : Cambridge University Press, 1970
Jahr Quelle:2021
Band/Heft Quelle:51(2021), 8, Seite 1329-1337
ISSN Quelle:1469-8978
Abstract:Background - Daily use of high-potency cannabis has been reported to carry a high risk for developing a psychotic disorder. However, the evidence is mixed on whether any pattern of cannabis use is associated with a particular symptomatology in first-episode psychosis (FEP) patients. - - Method - We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. We used item response modelling to estimate two bifactor models, which included general and specific dimensions of psychotic symptoms in patients and psychotic experiences in controls. The associations between these dimensions and cannabis use were evaluated using linear mixed-effects models analyses. - - Results - In patients, there was a linear relationship between the positive symptom dimension and the extent of lifetime exposure to cannabis, with daily users of high-potency cannabis having the highest score (B = 0.35; 95% CI 0.14-0.56). Moreover, negative symptoms were more common among patients who never used cannabis compared with those with any pattern of use (B = −0.22; 95% CI −0.37 to −0.07). In controls, psychotic experiences were associated with current use of cannabis but not with the extent of lifetime use. Neither patients nor controls presented differences in depressive dimension related to cannabis use. - - Conclusions - Our findings provide the first large-scale evidence that FEP patients with a history of daily use of high-potency cannabis present with more positive and less negative symptoms, compared with those who never used cannabis or used low-potency types.
DOI:doi:10.1017/S0033291720000082
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1017/S0033291720000082
 Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/daily-use-of-highpotency-cannabis-is-associated-w ...
 DOI: https://doi.org/10.1017/S0033291720000082
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cannabis use
 cannabis-associated psychosis
 first episode psychosis
 psychopathology
 psychotic experiences
 symptom dimensions
K10plus-PPN:1773861433
Verknüpfungen:→ Zeitschrift

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