| |  Online-Ressource |
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| Verfasst von: | Erenpreisa, Jekaterina [VerfasserIn]  |
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| | Krigerts, Jekabs [VerfasserIn] |
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| | Salmina, Kristine [VerfasserIn] |
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| | Gerashchenko, Bogdan I. [VerfasserIn] |
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| | Freivalds, Talivaldis [VerfasserIn] |
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| | Kurg, Reet [VerfasserIn] |
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| | Winter, Ruth [VerfasserIn] |
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| | Krufczik, Matthias [VerfasserIn] |
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| | Zayakin, Pawel [VerfasserIn] |
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| | Hausmann, Michael [VerfasserIn] |
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| | Giuliani, Alessandro [VerfasserIn] |
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| Titel: | Heterochromatin networks: topology, dynamics, and function (a working hypothesis) |
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| Verf.angabe: | Jekaterina Erenpreisa, Jekabs Krigerts, Kristine Salmina, Bogdan I. Gerashchenko, Talivaldis Freivalds, Reet Kurg, Ruth Winter, Matthias Krufczik, Pawel Zayakin, Michael Hausmann and Alessandro Giuliani |
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| E-Jahr: | 2021 |
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| Jahr: | 23 June 2021 |
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| Umfang: | 25 S. |
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| Teil: | volume:10 |
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| | year:2021 |
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| | number:7 |
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| | supplement:special issue |
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| | elocationid:1582 |
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| | pages:1-25 |
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| | extent:25 |
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| Fussnoten: | Gesehen am 20.10.2021 |
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| Titel Quelle: | Enthalten in: Cells |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 10(2021), 7, special issue, Artikel-ID 1582, Seite 1-25 |
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| ISSN Quelle: | 2073-4409 |
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| Abstract: | Open systems can only exist by self-organization as pulsing structures exchanging matter and energy with the outer world. This review is an attempt to reveal the organizational principles of the heterochromatin supra-intra-chromosomal network in terms of nonlinear thermodynamics. The accessibility of the linear information of the genetic code is regulated by constitutive heterochromatin (CHR) creating the positional information in a system of coordinates. These features include scale-free splitting-fusing of CHR with the boundary constraints of the nucleolus and nuclear envelope. The analysis of both the literature and our own data suggests a radial-concentric network as the main structural organization principle of CHR regulating transcriptional pulsing. The dynamic CHR network is likely created together with nucleolus-associated chromatin domains, while the alveoli of this network, including springy splicing speckles, are the pulsing transcription hubs. CHR contributes to this regulation due to the silencing position variegation effect, stickiness, and flexible rigidity determined by the positioning of nucleosomes. The whole system acts in concert with the elastic nuclear actomyosin network which also emerges by self-organization during the transcriptional pulsing process. We hypothesize that the the transcriptional pulsing, in turn, adjusts its frequency/amplitudes specified by topologically associating domains to the replication timing code that determines epigenetic differentiation memory. |
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| DOI: | doi:10.3390/cells10071582 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cells10071582 |
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| | Volltext: https://www.mdpi.com/2073-4409/10/7/1582 |
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| | DOI: https://doi.org/10.3390/cells10071582 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chromatin organization |
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| | cytoskeleton |
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| | heterochromatin |
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| | networks |
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| | nucleolar boundary |
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| | physics of life |
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| | positional information |
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| | scale-free oscillations |
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| | transcriptional pulsing |
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| K10plus-PPN: | 1774596016 |
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| Verknüpfungen: | → Zeitschrift |
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Heterochromatin networks: topology, dynamics, and function (a working hypothesis) / Erenpreisa, Jekaterina [VerfasserIn]; 23 June 2021 (Online-Ressource)
