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Verfasst von:Blank, Norbert [VerfasserIn]   i
 Schiller, Martin [VerfasserIn]   i
 Krienke, Stefan [VerfasserIn]   i
 Busse, Freja [VerfasserIn]   i
 Schätz, Birgit [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Kalden, Joachim R. [VerfasserIn]   i
 Lorenz, Hanns-Martin [VerfasserIn]   i
Titel:Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme
Titelzusatz:a reductase without decreasing cholesterol synthesis
Verf.angabe:Norbert Blank, Martin Schiller, Stefan Krienke, Freja Busse, Birgit Schätz, Anthony D. Ho, Joachim R. Kalden, and Hanns-Martin Lorenz
E-Jahr:2007
Jahr:[2007]
Umfang:9 S.
Illustrationen:Illustrationen
Teil:volume:179
 year:2007
 number:6
 pages:3613-3621
 extent:9
Fussnoten:Gesehen am 20.10.2021
Titel Quelle:Enthalten in: The journal of immunology
Ort Quelle:Bethesda, Md. : Soc., 1916
Jahr Quelle:2007
Band/Heft Quelle:179(2007), 6, Seite 3613-3621
ISSN Quelle:1550-6606
Abstract:The localization of the TCR and other signaling molecules in membrane rafts (MR) is essential for the activation of T lymphocytes. MR are stabilized by sphingolipids and cholesterol. Activation of T lymphocytes leads to the confluence of small MR and the formation of an immunological synapse that is essential for sustained activation and proliferation. In this study, we investigated the effect of statins on MR and T cell activation in superantigen-stimulated human PBMC. Atorvastatin significantly inhibited cellular activation and proliferation. The binding of cholera toxin B subunit to isolated MR and to whole cells was inhibited by low doses of statins. Statins reduce the association of critical signaling proteins such as Lck and linker of activation in T cells with MR in stimulated T cells. The expression of activation markers CD69 and CD25 was inhibited. Several statin-mediated mechanisms, such as a lower stimulation with MHC-II, an inhibition of costimulation by direct binding of statins to LFA-1, a reduced secretion of cytokines, or a depletion of cellular cholesterol pools, were excluded. Inhibition of protein prenylation had a similar effect on T cell proliferation, suggesting that a reduced protein prenylation might contribute to the statin-mediated inhibition of T cell activation. Statins induce both lower levels of low-density lipoprotein cholesterol and inhibition of T cell activation, which might contribute to an inhibition of atherosclerosis.
DOI:doi:10.4049/jimmunol.179.6.3613
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.4049/jimmunol.179.6.3613
 Volltext: https://www.jimmunol.org/content/179/6/3613
 DOI: https://doi.org/10.4049/jimmunol.179.6.3613
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1774618958
Verknüpfungen:→ Zeitschrift

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