| |  Online-Ressource |
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| Verfasst von: | Patzelt, Lisa [VerfasserIn]  |
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| | Junker, Daniela [VerfasserIn] |
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| | Syväri, Jan [VerfasserIn] |
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| | Burian, Egon [VerfasserIn] |
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| | Wu, Mingming [VerfasserIn] |
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| | Prokopchuk, Olga [VerfasserIn] |
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| | Nitsche, Ulrich [VerfasserIn] |
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| | Makowski, Marcus R. [VerfasserIn] |
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| | Braren, Rickmer F. [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| | Diaz, Mauricio Berriel [VerfasserIn] |
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| | Karampinos, Dimitrios C. [VerfasserIn] |
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| Titel: | MRI-determined psoas muscle fat infiltration correlates with severity of weight loss during cancer cachexia |
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| Verf.angabe: | Lisa Patzelt, Daniela Junker, Jan Syväri, Egon Burian, Mingming Wu, Olga Prokopchuk, Ulrich Nitsche, Marcus R. Makowski, Rickmer F. Braren, Stephan Herzig, Mauricio Berriel Diaz and Dimitrios C. Karampinos |
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| E-Jahr: | 2021 |
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| Jahr: | 2 September 2021 |
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| Umfang: | 15 S. |
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| Teil: | volume:13 |
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| | year:2021 |
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| | number:17 |
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| | elocationid:4433 |
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| | pages:1-15 |
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| | extent:15 |
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| Fussnoten: | Gesehen am 21.10.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 17, Artikel-ID 4433, Seite 1-15 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Purpose: To evaluate the suitability of psoas and erector spinae muscle proton density fat fraction (PDFF) and fat volume as biomarkers for monitoring cachexia severity in an oncological cohort, and to evaluate regional variances in muscle parameters over time. Methods: In this prospective study, 58 oncological patients were examined by a 3 T MRI receiving between one and five scans. Muscle volume and PDFF were measured, segmentation masks were divided into proximal, middle and distal muscle section. Results: A regional variation of fat distribution in erector spinae muscle at baseline was found (p < 0.01). During follow-ups significant relative change of muscle parameters was observed. Relative maximum change of erector spinae muscle showed a significant regional variation. Correlation testing with age as a covariate revealed significant correlations for baseline psoas fat volume (r = −0.55, p < 0.01) and baseline psoas PDFF (r = −0.52, p = 0.02) with maximum BMI change during the course of the disease. Conclusion: In erector spinae muscles, a regional variation of fat distribution at baseline and relative maximum change of muscle parameters was observed. Our results indicate that psoas muscle PDFF and fat volume could serve as MRI-determined biomarkers for early risk stratification and disease monitoring regarding progression and severity of weight loss in cancer cachexia. |
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| DOI: | doi:10.3390/cancers13174433 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers13174433 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/17/4433 |
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| | DOI: https://doi.org/10.3390/cancers13174433 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer cachexia |
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| | magnetic resonance imaging |
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| | proton density fat fraction (PDFF) |
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| | skeletal muscle |
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| | weight loss |
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| K10plus-PPN: | 1774689723 |
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| Verknüpfungen: | → Zeitschrift |
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MRI-determined psoas muscle fat infiltration correlates with severity of weight loss during cancer cachexia / Patzelt, Lisa [VerfasserIn]; 2 September 2021 (Online-Ressource)
