The beauty of asymmetry

• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Verfasst von: Wagner, Wolfgang [VerfasserIn]
• Titel: The beauty of asymmetry
• Titelzusatz: asymmetric divisions and self-renewal in the haematopoietic system
• Verf.angabe: Anthony D. Ho and Wolfgang Wagner
• E-Jahr: 2007
• Jahr: [2007]
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 26.10.2021
• Titel Quelle: Enthalten in: Current opinion in hematology
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1994
• Jahr Quelle: 2007
• Band/Heft Quelle: 14(2007), 4, Seite 330-336
• ISSN Quelle: 1531-7048
• DOI: doi:10.1097/MOH.0b013e3281900f12
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1775295435

Abstract

Purpose of review - The hallmark of stem cells is their dual abilities to self-renew and to differentiate into multiple lineages. To fulfill these functions they must undergo asymmetric division. A central question in developmental biology is how can a single cell divide to produce two progeny cells that adopt different fates? We provided evidence of the significance of asymmetric division in human haematopoietic stem cells. - Recent findings - By monitoring the symmetry of divisions of haematopoietic stem cells and following their subsequent developmental potentials at the single cell level, we established a relationship between divisional kinetics and self-renewal capacity. Direct cell-cell contact with cellular determinants in the niche has been shown to play an essential role in maintaining stemness. The creation of in-vitro models for the niche, such as human mesenchymal stromal cells, has provided a controlled laboratory environment in which the relative significance of chemokines and adhesion molecules can be studied. - Summary - Identification of the molecular interactions between stem cells and their niche has led to an understanding of the mechanisms that control the self-renewal of stem cells. Ultimately, molecular signals triggered by adhesion and junction complexes are responsible for the adoption of specific cell fate.