| |  Online-Ressource |
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| Verfasst von: | Rodionova, Elena [VerfasserIn]  |
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| | Conzelmann, Michael [VerfasserIn] |
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| | Maraskovsky, Eugene [VerfasserIn] |
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| | Hess, Michael [VerfasserIn] |
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| | Kirsch, Michael [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Zöller, Margot [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Luft, Thomas [VerfasserIn] |
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| Titel: | GSK-3 mediates differentiation and activation of proinflammatory dendritic cells |
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| Verf.angabe: | Elena Rodionova, Michael Conzelmann, Eugene Maraskovsky, Michael Hess, Michael Kirsch, Thomas Giese, Anthony D. Ho, Margot Zöller, Peter Dreger, Thomas Luft |
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| E-Jahr: | 2007 |
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| Jahr: | [15 February 2007] |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Teil: | volume:109 |
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| | year:2007 |
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| | number:4 |
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| | pages:1584-1592 |
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| | extent:9 |
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| Fussnoten: | Prepublished online as Blood first edition paper, October 10, 2006 ; Gesehen am 26.10.2021 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2007 |
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| Band/Heft Quelle: | 109(2007), 4, Seite 1584-1592 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | The key components of the intracellular molecular network required for the expression of a specific function of dendritic cells (DCs) are as yet undefined. Using an in vitro model of human monocyte-derived DC differentiation, this study investigates the role of glycogen synthase kinase 3 (GSK-3), a multifunctional enzyme critical for cellular differentiation, apoptosis, self-renewal, and motility, in this context. We demonstrate that GSK-3 (1) inhibits macrophage development during differentiation of DCs, (2) is constitutively active in immature DCs and suppresses spontaneous maturation, and (3) acquires a proinflammatory functional status mediating high levels of IL-12, IL-6, and TNF-α secretion, and partially inhibits IL-10 in the context of DC activation. In particular, GSK-3 enhances IL-12p35 mRNA expression and thus the production of the proinflammatory cytokine IL-12p70 by integrating the activities of other kinases priming GSK-3 targets and the inhibitory effects of Akt-1. GSK-3 may therefore act as a key integrator of activating and inhibitory pathways involved in proinflammatory DC differentiation and activation. |
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| DOI: | doi:10.1182/blood-2006-06-028951 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1182/blood-2006-06-028951 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120420014 |
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| | DOI: https://doi.org/10.1182/blood-2006-06-028951 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1775296784 |
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| Verknüpfungen: | → Zeitschrift |
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GSK-3 mediates differentiation and activation of proinflammatory dendritic cells / Rodionova, Elena [VerfasserIn]; [15 February 2007] (Online-Ressource)
