| |  Online-Ressource |
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| Verfasst von: | Krause, Ulf [VerfasserIn]  |
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| | Harter, Christoph [VerfasserIn] |
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| | Seckinger, Anja [VerfasserIn] |
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| | Wolf, David Gregor [VerfasserIn] |
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| | Reinhardt, Adrian [VerfasserIn] |
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| | Bea, Florian [VerfasserIn] |
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| | Dengler, Thomas [VerfasserIn] |
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| | Hardt, Stefan [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Kücherer, Helmut [VerfasserIn] |
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| | Hansen, Alexander E. W. [VerfasserIn] |
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| Titel: | Intravenous delivery of autologous mesenchymal stem cells limits infarct size and improves left ventricular function in the infarcted porcine heart |
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| Verf.angabe: | Ulf Krause, Christoph Harter, Anja Seckinger, David Wolf, Adrian Reinhard, Florian Bea, Thomas Dengler, Stefan Hardt, Anthony Ho, Hugo A. Katus, Helmut Kuecherer, and Alexander Hansen |
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| E-Jahr: | 2007 |
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| Jahr: | 11 Mar 2007 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 26.10.2021 |
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| Titel Quelle: | Enthalten in: Stem Cells and Development |
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| Ort Quelle: | Larchmont, NY : Liebert, 2004 |
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| Jahr Quelle: | 2007 |
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| Band/Heft Quelle: | 16(2007), 1, Seite 31-38 |
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| ISSN Quelle: | 1557-8534 |
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| Abstract: | Systemic delivery of bone marrow-derived mesenchymal stem cells (MSCs) is a noninvasive approach for myocardial repair. We aimed to test this strategy in a pig model of myocardial infarction. Pigs (n = 8) received autologous MSCs (1 x 106/kg body weight) labeled with fluorescent dye 48 h post proximal left anterior descending artery (LAD) occlusion. Hemodyamics, infarct size, and myocardial function were assessed at baseline and after 1 month. Morphologic analysis revealed that labeled MSCs migrated in the peri-infarct region, resulting in smaller infarct size (32 ± 7 vs. 19 ± 7%, p = 0.01), higher fractional area shortening (23 ± 3 vs. 34.0 ± 7%, p = 0.001), lower left ventricular end diastolic pressure (18.7 ± 5 vs. 10.2 ± 4 mmHg, p = 0.02) and higher +dp/dt (4,570 ± 540 vs. 6,742 ± 700 mmHg/s, p = 0.03) during inotropic stimulation. Systemic intravenous delivery of MSCs to pigs limits myocardial infarct size and is an attractive approach for tissue repair. |
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| DOI: | doi:10.1089/scd.2006.0089 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1089/scd.2006.0089 |
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| | Volltext: https://www.liebertpub.com/doi/10.1089/scd.2006.0089 |
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| | DOI: https://doi.org/10.1089/scd.2006.0089 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1775304736 |
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| Verknüpfungen: | → Zeitschrift |
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Intravenous delivery of autologous mesenchymal stem cells limits infarct size and improves left ventricular function in the infarcted porcine heart / Krause, Ulf [VerfasserIn]; 11 Mar 2007 (Online-Ressource)
