| |  Online-Ressource |
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| Verfasst von: | Martínez Vergara, Hernando [VerfasserIn]  |
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| | Pape, Constantin [VerfasserIn] |
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| | Meechan, Kimberly [VerfasserIn] |
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| | Zinchenko, Valentyna [VerfasserIn] |
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| | Genoud, Christel [VerfasserIn] |
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| | Wanner, Adrian A. [VerfasserIn] |
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| | Mutemi, Kevin Nzumbi [VerfasserIn] |
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| | Titze, Benjamin [VerfasserIn] |
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| | Templin, Rachel M. [VerfasserIn] |
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| | Bertucci, Paola Y. [VerfasserIn] |
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| | Simakov, Oleg [VerfasserIn] |
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| | Dürichen, Wiebke [VerfasserIn] |
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| | Machado, Pedro [VerfasserIn] |
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| | Savage, Emily L. [VerfasserIn] |
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| | Schermelleh, Lothar [VerfasserIn] |
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| | Schwab, Yannick [VerfasserIn] |
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| | Friedrich, Rainer W. [VerfasserIn] |
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| | Kreshuk, Anna [VerfasserIn] |
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| | Tischer, Christian [VerfasserIn] |
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| | Arendt, Detlev [VerfasserIn] |
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| Titel: | Whole-body integration of gene expression and single-cell morphology |
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| Verf.angabe: | Hernando M. Vergara, Constantin Pape, Kimberly I. Meechan, Valentyna Zinchenko, Christel Genoud, Adrian A. Wanner, Kevin Nzumbi Mutemi, Benjamin Titze, Rachel M. Templin, Paola Y. Bertucci, Oleg Simakov, Wiebke Dürichen, Pedro Machado, Emily L. Savage, Lothar Schermelleh, Yannick Schwab, Rainer W. Friedrich, Anna Kreshuk, Christian Tischer, Detlev Arendt |
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| E-Jahr: | 2021 |
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| Jahr: | 10 August 2021 |
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| Umfang: | 42 S. |
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| Fussnoten: | Gesehen am 26.10.2021 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 184(2021), 18, Seite 4819-4837.e22 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | Animal bodies are composed of cell types with unique expression programs that implement their distinct locations, shapes, structures, and functions. Based on these properties, cell types assemble into specific tissues and organs. To systematically explore the link between cell-type-specific gene expression and morphology, we registered an expression atlas to a whole-body electron microscopy volume of the nereid Platynereis dumerilii. Automated segmentation of cells and nuclei identifies major cell classes and establishes a link between gene activation, chromatin topography, and nuclear size. Clustering of segmented cells according to gene expression reveals spatially coherent tissues. In the brain, genetically defined groups of neurons match ganglionic nuclei with coherent projections. Besides interneurons, we uncover sensory-neurosecretory cells in the nereid mushroom bodies, which thus qualify as sensory organs. They furthermore resemble the vertebrate telencephalon by molecular anatomy. We provide an integrated browser as a Fiji plugin for remote exploration of all available multimodal datasets. |
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| DOI: | doi:10.1016/j.cell.2021.07.017 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2021.07.017 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S009286742100876X |
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| | DOI: https://doi.org/10.1016/j.cell.2021.07.017 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | automatic segmentation |
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| | cell types |
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| | gene expression atlas |
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| | image registration |
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| | machine learning |
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| | multimodal data integration |
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| | mushroom bodies |
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| | telencephalon |
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| | volume electron microscopy |
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| K10plus-PPN: | 1775321320 |
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| Verknüpfungen: | → Zeitschrift |
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Whole-body integration of gene expression and single-cell morphology / Martínez Vergara, Hernando [VerfasserIn]; 10 August 2021 (Online-Ressource)
