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Verfasst von:Pinkert, Sandra [VerfasserIn]   i
 Kespohl, Meike [VerfasserIn]   i
 Kelm, Nicolas [VerfasserIn]   i
 Kaya, Ziya [VerfasserIn]   i
 Heuser, Arnd [VerfasserIn]   i
 Klingel, Karin [VerfasserIn]   i
 Beling, Antje [VerfasserIn]   i
Titel:Exploration of analgesia with tramadol in the coxsackievirus B3 myocarditis mouse model
Verf.angabe:Sandra Pinkert, Meike Kespohl, Nicolas Kelm, Ziya Kaya, Arnd Heuser, Karin Klingel and Antje Beling
E-Jahr:2021
Jahr:24 June 2021
Umfang:15 S.
Fussnoten:Gesehen am 27.10.2021
Titel Quelle:Enthalten in: Viruses
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2021
Band/Heft Quelle:13(2021), 7, special issue, Artikel-ID 1222, Seite 1-15
ISSN Quelle:1999-4915
Abstract:Infection of mice with Coxsackievirus B3 (CVB3) triggers inflammation of the heart and this mouse model is commonly used to investigate underlying mechanisms and therapeutic aspects for viral myocarditis. Virus-triggered cytotoxicity and the activity of infiltrating immune cells contribute to cardiac tissue injury. In addition to cardiac manifestation, CVB3 causes cell death and inflammation in the pancreas. The resulting pancreatitis represents a severe burden and under such experimental conditions, analgesics may be supportive to improve the animals’ well-being. Notably, several known mechanisms exist by which analgesics can interfere with the immune system and thereby compromise the feasibility of the model. We set up a study aiming to improve animal welfare while ensuring model integrity and investigated how tramadol, an opioid, affects virus-induced pathogenicity and immune response in the heart. Tramadol was administered seven days prior to a CVB3 infection in C57BL/6 mice and treatment was continued until the day of analysis. Tramadol had no effect on the virus titer or viral pathogenicity in the heart tissue and the inflammatory response, a hallmark of myocardial injury, was maintained. Our results show that tramadol exerts no disruptive effects on the CVB3 myocarditis mouse model and, therefore, the demonstrated protocol should be considered as a general analgesic strategy for CVB3 infection.
DOI:doi:10.3390/v13071222
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/v13071222
 Volltext: https://www.mdpi.com/1999-4915/13/7/1222
 DOI: https://doi.org/10.3390/v13071222
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:analgesia
 infection
 myocarditis
 pancreatitis
 refinement
K10plus-PPN:1775536726
Verknüpfungen:→ Zeitschrift

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