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Verfasst von:Klein, Valerie [VerfasserIn]   i
 Davids, Mathias [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
 Wald, Lawrence [VerfasserIn]   i
 Guerin, Bastien [VerfasserIn]   i
Titel:Investigating cardiac stimulation limits of MRI gradient coils using electromagnetic and electrophysiological simulations in human and canine body models
Verf.angabe:Valerie Klein, Mathias Davids, Lothar R. Schad, Lawrence L. Wald, Bastien Guérin
Jahr:2021
Umfang:15 S.
Fussnoten:First published: 19 August 2020 ; Gesehen am 28.10.2021
Titel Quelle:Enthalten in: Magnetic resonance in medicine
Ort Quelle:New York, NY [u.a.] : Wiley-Liss, 1984
Jahr Quelle:2021
Band/Heft Quelle:85(2021), 2, Seite 1047-1061
ISSN Quelle:1522-2594
Abstract:Purpose Cardiac stimulation (CS) limits to gradient coil switching speed are difficult to measure in humans; instead, current regulatory guidelines (IEC 60601-2-33) are based on animal experiments and electric field-to-dB/dt conversion factors computed for a simple, homogeneous body model. We propose improvement to this methodology by using more detailed CS modeling based on realistic body models and electrophysiological models of excitable cardiac fibers. Methods We compute electric fields induced by a solenoid, coplanar loops, and a commercial gradient coil in two human body models and a canine model. The canine simulations mimic previously published experiments. We generate realistic fiber topologies for the cardiac Purkinje and ventricular muscle fiber networks using rule-based algorithms, and evaluate CS thresholds using validated electrodynamic models of these fibers. Results We were able to reproduce the average measured canine CS thresholds within 5%. In all simulations, the Purkinje fibers were stimulated before the ventricular fibers, and therefore set the effective CS threshold. For the investigated gradient coil, simulated CS thresholds for the x-, y-, and z-axis were at least one order of magnitude greater than the International Electrotechnical Commission limit. Conclusion We demonstrate an approach to simulate gradient-induced CS using a combination of electromagnetic and electrophysiological modeling. Pending additional validation, these simulations could guide the assessment of CS limits to MRI gradient coil switching speed. Such an approach may lead to less conservative, but still safe, operation limits, enabling the use of the maximum gradient amplitude versus slew rate parameter space of recent, powerful gradient systems.
DOI:doi:10.1002/mrm.28472
URL:kostenfrei: Volltext: https://doi.org/10.1002/mrm.28472
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.28472
 DOI: https://doi.org/10.1002/mrm.28472
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Errata: Klein, Valerie, 1992 - : Erratum to “Investigating cardiac stimulation limits of MRI gradient coils using electromagnetic and electrophysiological simulations in human and canine body models” (MRM 2021, 85[2]:1047-1061)
Sach-SW:cardiac stimulation
 electromagnetic exposure safety
 electromagnetic field simulation
 heart model
 magnetostimulation thresholds
 MRI gradient field switching
K10plus-PPN:1775675750
Verknüpfungen:→ Zeitschrift
 
 
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