Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma

• Verfasst von: Hillengaß, Jens [VerfasserIn]
• Verfasst von: Wasser, Klaus [VerfasserIn]
• Verfasst von: Delorme, Stefan [VerfasserIn]
• Verfasst von: Kießling, Fabian [VerfasserIn]
• Verfasst von: Zechmann, Christian [VerfasserIn]
• Verfasst von: Benner, Axel [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Verfasst von: Möhler, Thomas [VerfasserIn]
• Titel: Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma
• Verf.angabe: Jens Hillengass, Klaus Wasser, Stefan Delorme, Fabian Kiessling, Christian Zechmann, Axel Benner, Hans-Ulrich Kauczor, Anthony D. Ho, Hartmut Goldschmidt, and Thomas M. Moehler
• E-Jahr: 2007
• Jahr: [January 2007]
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 02.11.2021
• Titel Quelle: Enthalten in: Clinical cancer research
• Ort Quelle: Philadelphia, Pa. [u.a.] : AACR, 1995
• Jahr Quelle: 2007
• Band/Heft Quelle: 13(2007), 2, Seite 475-481
• ISSN Quelle: 1557-3265
• DOI: doi:10.1158/1078-0432.CCR-06-0061
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1775871479

Abstract

Purpose: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with high temporal resolution enables the detection of microcirculation variables amplitude A and exchange rate constant kep. In this study, the prognostic value of the DCE-MRI variables for overall survival and event-free survival in patients with progressive multiple myeloma was investigated. - Experimental Design: Between 1999 and 2001, 65 patients with progressive or relapse of multiple myeloma requiring therapy were investigated with DCE-MRI of the lumbar spine before start of therapy. The contrast uptake was quantified using a two-compartment model with the output variables amplitude A and exchange rate constant kep reflecting bone marrow microcirculation. The estimated median follow-up was 56 months. Event-free survival and overall survival were investigated for DCE-MRI variables and for established prognosis variables (β2-microglobulin, lactate dehydrogenase, albumin, and age). - Results: Using a multivariate Cox regression model, β2-microglobulin and amplitude A of DCE-MRI were identified as statistically significant prognostic variable of event-free survival with Ps of 0.01 and 0.02, respectively. A statistical correlation of DCE-MRI variables with overall survival could not be found. The multivariate analysis of β2-microglobulin, age, lactate dehydrogenase, and albumin revealed β2-microglobulin as statistically significant prognostic factor for overall survival in this group of patients (P < 0.001). - Conclusions: This analysis identifies contrast-enhanced DCE-MRI variable amplitude A reflecting increased bone marrow microcirculation and angiogenesis as a novel and possibly useful prognostic factor in patients with multiple myeloma. Prospective studies are currently done to further investigate this functional variable for prognosis and stratification of myeloma patients.