| |  Online-Ressource |
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| Verfasst von: | Remes, Anca [VerfasserIn]  |
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| | Wagner, Andreas H. [VerfasserIn] |
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| | Schmiedel, Nesrin [VerfasserIn] |
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| | Heckmann, Markus B. [VerfasserIn] |
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| | Ruf, Theresa [VerfasserIn] |
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| | Ding, Lin [VerfasserIn] |
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| | Jungmann, Andreas [VerfasserIn] |
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| | Senger, Frauke [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Ullrich, Nina D. [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| | Hecker, Markus [VerfasserIn] |
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| | Müller, Oliver J. [VerfasserIn] |
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| Titel: | AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure |
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| Verf.angabe: | Anca Remes, Andreas H. Wagner, Nesrin Schmiedel, Markus Heckmann, Theresa Ruf, Lin Ding, Andreas Jungmann, Frauke Senger, Hugo A. Katus, Nina D. Ullrich, Norbert Frey, Markus Hecker, Oliver J. Müller |
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| E-Jahr: | 2021 |
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| Jahr: | 04 June 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 04.11.2021 |
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| Titel Quelle: | Enthalten in: Basic research in cardiology |
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| Ort Quelle: | [Darmstadt u.a.] : Steinkopff, 1937 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 116(2021), Artikel-ID 38, Seite 1-12 |
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| ISSN Quelle: | 1435-1803 |
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| Abstract: | Previous studies have underlined the substantial role of nuclear factor of activated T cells (NFAT) in hypertension-induced myocardial hypertrophy ultimately leading to heart failure. Here, we aimed at neutralizing four members of the NFAT family of transcription factors as a therapeutic strategy for myocardial hypertrophy transiting to heart failure through AAV-mediated cardiac expression of a RNA-based decoy oligonucleotide (dON) targeting NFATc1-c4. AAV-mediated dON expression markedly decreased endothelin-1 induced cardiomyocyte hypertrophy in vitro and resulted in efficient expression of these dONs in the heart of adult mice as evidenced by fluorescent in situ hybridization. Cardiomyocyte-specific dON expression both before and after induction of transverse aortic constriction protected mice from development of cardiac hypertrophy, cardiac remodeling, and heart failure. Singular systemic administration of AAVs enabling a cell-specific expression of dONs for selective neutralization of a given transcription factor may thus represent a novel and powerful therapeutic approach. |
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| DOI: | doi:10.1007/s00395-021-00880-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00395-021-00880-w |
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| | Volltext: https://link.springer.com/article/10.1007%2Fs00395-021-00880-w |
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| | DOI: https://doi.org/10.1007/s00395-021-00880-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1776170407 |
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| Verknüpfungen: | → Zeitschrift |
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AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure / Remes, Anca [VerfasserIn]; 04 June 2021 (Online-Ressource)
