Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization

• Verfasst von: Mahlknecht, Ulrich Rudolph [VerfasserIn]
• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Verfasst von: Letzel, Stephan [VerfasserIn]
• Verfasst von: Völter-Mahlknecht, Susanne Friederike [VerfasserIn]
• Titel: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization
• Verf.angabe: U. Mahlknecht, A.D. Ho, S. Letzel, S. Voelter-Mahlknecht
• E-Jahr: 2006
• Jahr: February 2006
• Umfang: 5 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 05.11.2021
• Titel Quelle: Enthalten in: Cytogenetic and genome research
• Ort Quelle: Basel : Karger, 2002
• Jahr Quelle: 2006
• Band/Heft Quelle: 112(2006), 3-4, Seite 208-212
• ISSN Quelle: 1424-859X
• DOI: doi:10.1159/000089872
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 177627590X

Abstract

Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase and belongs to the Silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs), which play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the human SIRT5 genomic sequence, which spans a region of 28,182 bp and which has one single genomic locus. Human SIRT5 consists of eight exons and is found in two isoforms, which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23.