| |  Online-Ressource |
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| Verfasst von: | Munder, Markus [VerfasserIn]  |
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| | Rudolph, Henriette [VerfasserIn] |
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| | Luckner-Minden, Claudia [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| | Langhans, Claus-Dieter [VerfasserIn] |
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| | Fuentes, Jose M. [VerfasserIn] |
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| | Kropf, Pascale [VerfasserIn] |
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| | Mueller, Ingrid [VerfasserIn] |
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| | Kolb, Armin [VerfasserIn] |
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| | Modolell, Manuel [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| Titel: | Suppression of T-cell functions by human granulocyte arginase |
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| Verf.angabe: | Markus Munder, Henriette Schneider, Claudia Luckner, Thomas Giese, Claus-Dieter Langhans, Jose M. Fuentes, Pascale Kropf, Ingrid Mueller, Armin Kolb, Manuel Modolell, and Anthony D. Ho |
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| E-Jahr: | 2006 |
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| Jahr: | September 1, 2006 |
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| Umfang: | 8 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Prepublished online as Blood first edition paper, May 18, 2006 ; Gesehen am 09.11.2021 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2006 |
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| Band/Heft Quelle: | 108(2006), 5, Seite 1627-1634 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | Chronic inflammation is accompanied by impaired T-cell immunity. In the mouse, myeloid cell-associated arginase accounts for the suppression of immune reactivity in various models of tumor growth and chronic infections. Here we show that arginase I is liberated from human granulocytes, and very high activities accumulate extracellularly during purulent inflammatory reactions. Human granulocyte arginase induces a profound suppression of T-cell proliferation and cytokine synthesis. This T-cell phenotype is due to arginase-mediated depletion of arginine in the T-cell environment, which leads to CD3ζ chain down-regulation but does not alter T-cell viability. Our study therefore demonstrates that human granulocytes possess a previously unanticipated immunosuppressive effector function. Human granulocyte arginase is a promising pharmacologic target to reverse unwanted immunosuppression. |
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| DOI: | doi:10.1182/blood-2006-11-010389 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2006-11-010389 |
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| | DOI: https://doi.org/10.1182/blood-2006-11-010389 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1776479327 |
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| Verknüpfungen: | → Zeitschrift |
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Suppression of T-cell functions by human granulocyte arginase / Munder, Markus [VerfasserIn]; September 1, 2006 (Online-Ressource)
