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| Verfasst von: | Eisele, Yannick [VerfasserIn]  |
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| | Mallea, Patrick M. [VerfasserIn] |
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| | Gigić, Biljana [VerfasserIn] |
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| | Stephens, W. Zac [VerfasserIn] |
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| | Warby, Christy A. [VerfasserIn] |
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| | Buhrke, Kate [VerfasserIn] |
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| | Lin, Tengda [VerfasserIn] |
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| | Boehm, Juergen [VerfasserIn] |
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| | Schrotz-King, Petra [VerfasserIn] |
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| | Hardikar, Sheetal [VerfasserIn] |
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| | Huang, Lyen C. [VerfasserIn] |
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| | Pickron, T. Bartley [VerfasserIn] |
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| | Scaife, Courtney L. [VerfasserIn] |
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| | Viskochil, Richard [VerfasserIn] |
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| | Kölsch, Torsten [VerfasserIn] |
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| | Peoples, Anita R. [VerfasserIn] |
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| | Pletneva, Maria A. [VerfasserIn] |
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| | Bronner, Mary [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Ulrich, Alexis [VerfasserIn] |
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| | Swanson, Eric A. [VerfasserIn] |
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| | Toriola, Adetunji T. [VerfasserIn] |
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| | Shibata, David [VerfasserIn] |
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| | Li, Christopher I. [VerfasserIn] |
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| | Siegel, Erin M. [VerfasserIn] |
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| | Figueiredo, Jane [VerfasserIn] |
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| | Janssen, Klaus-Peter [VerfasserIn] |
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| | Hauner, Hans [VerfasserIn] |
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| | Round, June [VerfasserIn] |
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| | Ulrich, Cornelia [VerfasserIn] |
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| | Holowatyj, Andreana N. [VerfasserIn] |
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| | Ose, Jennifer [VerfasserIn] |
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| Titel: | Fusobacterium nucleatum and clinicopathologic features of colorectal cancer |
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| Titelzusatz: | results from the ColoCare study |
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| Verf.angabe: | Yannick Eisele, Patrick M. Mallea, Biljana Gigic, W. Zac Stephens, Christy A. Warby, Kate Buhrke, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Sheetal Hardikar, Lyen C. Huang, T. Bartley Pickron, Courtney L. Scaife, Richard Viskochil, Torsten Koelsch, Anita R. Peoples, Maria A. Pletneva, Mary Bronner, Martin Schneider, Alexis B. Ulrich, Eric A. Swanson, Adetunji T. Toriola, David Shibata, Christopher I. Li, Erin M. Siegel, Jane Figueiredo, Klaus-Peter Janssen, Hans Hauner, June Round, Cornelia M. Ulrich, Andreana N. Holowatyj, Jennifer Ose |
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| E-Jahr: | 2021 |
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| Jahr: | 27 February 2021 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 10.11.2021 |
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| Titel Quelle: | Enthalten in: Clinical colorectal cancer and other gastrointestinal malignancies |
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| Ort Quelle: | New York, NY [u.a.] : Elsevier, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 20(2021), 3 vom: Sept., Seite e165-e172 |
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| ISSN Quelle: | 1938-0674 |
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| Abstract: | Background - Fusobacterium nucleatum (Fn), a bacterium associated with a wide spectrum of infections, has emerged as a key microbe in colorectal carcinogenesis. However, the underlying mechanisms and clinical relevance of Fn in colorectal cancer (CRC) remain incompletely understood. - Patients and Methods - We examined associations between Fn abundance and clinicopathologic characteristics among 105 treatment-naïve CRC patients enrolled in the international, prospective ColoCare Study. Electronic medical charts, including pathological reports, were reviewed to document clinicopathologic features. Quantitative real-time polymerase chain reaction (PCR) was used to amplify/detect Fn DNA in preoperative fecal samples. Multinomial logistic regression was used to analyze associations between Fn abundance and patient sex, age, tumor stage, grade, site, microsatellite instability, body mass index (BMI), alcohol consumption, and smoking history. Cox proportional hazards models were used to investigate associations of Fn abundance with overall survival in adjusted models. - Results - Compared to patients with undetectable or low Fn abundance, patients with high Fn abundance (n = 22) were 3-fold more likely to be diagnosed with rectal versus colon cancer (odds ratio [OR] = 3.01; 95% confidence interval [CI], 1.06-8.57; P = .04) after adjustment for patient sex, age, BMI, and study site. Patients with high Fn abundance also had a 5-fold increased risk of being diagnosed with rectal cancer versus right-sided colon cancer (OR = 5.32; 95% CI, 1.23-22.98; P = .03). There was no statistically significant association between Fn abundance and overall survival. - Conclusion - Our findings suggest that Fn abundance in fecal samples collected prior to surgery varies by tumor site among treatment-naïve CRC patients. Overall, fecal Fn abundance may have diagnostic and prognostic significance in the clinical management of CRC. |
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| DOI: | doi:10.1016/j.clcc.2021.02.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.clcc.2021.02.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1533002821000219 |
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| | DOI: https://doi.org/10.1016/j.clcc.2021.02.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Fusobacterium |
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| | gut microbiome |
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| | rectal cancer |
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| | stool |
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| | tumor site |
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| K10plus-PPN: | 1777105005 |
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| Verknüpfungen: | → Zeitschrift |
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Fusobacterium nucleatum and clinicopathologic features of colorectal cancer / Eisele, Yannick [VerfasserIn]; 27 February 2021 (Online-Ressource)
