Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type

• Verfasst von: Pantel, Johannes [VerfasserIn]
• Verfasst von: Schröder, Johannes [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Friedlinger, Michael [VerfasserIn]
• Verfasst von: Knopp, Michael V. [VerfasserIn]
• Verfasst von: Schmitt, R. [VerfasserIn]
• Verfasst von: Geissler, M. [VerfasserIn]
• Verfasst von: Blüml, S. [VerfasserIn]
• Verfasst von: Essig, Marco [VerfasserIn]
• Verfasst von: Sauer, H. [VerfasserIn]
• Titel: Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type
• Verf.angabe: J. Pantel, J. Schröder, L.R. Schad, M. Friedlinger, M.V. Knopp, R. Schmitt, M. Geissler, S. Blüml, M. Essig, H. Sauer
• E-Jahr: 1997
• Jahr: 01 January 1997
• Umfang: 9 S.
• Fussnoten: Gesehen am 10.11.2021
• Titel Quelle: Enthalten in: Psychopharmacology
• Ort Quelle: Berlin : Springer, 1959
• Jahr Quelle: 1997
• Band/Heft Quelle: 27(1997), 1, Seite 221-229
• ISSN Quelle: 1432-2072
• DOI: doi:10.1017/S003329179600431X
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1777148596

Abstract

Background. The aim of the present study was to investigate neuropsychological functions in - dementia of the Alzheimer type (DAT) with respect to morphological changes that were revealed - by quantitative magnetic resonance imaging (MRI).Methods. Twenty patients with DAT (NINCDS-ADRDA criteria) and 10 healthy age and sex - matched controls were included. The neuropsychological function was evaluated on a test - battery covering the severity of dementia, verbal and visual memory, concentration and - attention, language skills and general intelligence as well as activities of daily living. 3D MRI - sequences were acquired using a 1.5 T Siemens MAGNETOM. Whole brain volume, total - intracranial volume (TIV), volume of the frontal and temporal lobes and volumes of the - amygdalahippocampus complex (AHC) were assessed using the newly developed software NMRWin.Results. Apart from TIV all morphometric parameters differed significantly between the - diagnostic groups. AHC volumes discriminated best between the groups, with only a small overlap. - AHC atrophy exceeded generalized atrophy. These findings were confirmed when the data were - reanalysed after dividing the DAT patients into a mildly and moderately affected group. The - severity of dementia was significantly correlated with the volumes of the AHC and the volumes - of the temporal lobes bilaterally, but not with the whole brain volume and the volumes of the - frontal lobes.Conclusions. These results underline the important role of the temporal substructures for - aetiology and progression of DAT. They indicate that the volume of the AHC can be - monitored by MRI and may be used to follow up the disease process.