| |  Online-Ressource |
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| Verfasst von: | Simon, Caroline [VerfasserIn]  |
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| | Funaya, Charlotta [VerfasserIn] |
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| | Bauer, Johanna [VerfasserIn] |
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| | Voss, Yannik [VerfasserIn] |
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| | Machado, Marta [VerfasserIn] |
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| | Penning, Alexander [VerfasserIn] |
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| | Klaschka, Darius [VerfasserIn] |
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| | Cyrklaff, Marek [VerfasserIn] |
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| | Kim, Juyeop [VerfasserIn] |
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| | Ganter, Markus [VerfasserIn] |
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| | Guizetti, Julien [VerfasserIn] |
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| Titel: | An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites |
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| Verf.angabe: | Caroline S Simon, Charlotta Funaya, Johanna Bauer, Yannik Voβ, Marta Machado, Alexander Penning, Darius Klaschka, Marek Cyrklaff, Juyeop Kim, Markus Ganter, Julien Guizetti |
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| E-Jahr: | 2021 |
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| Jahr: | 17 September 2021 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 11.11.2021 |
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| Titel Quelle: | Enthalten in: Life science alliance |
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| Ort Quelle: | Heidelberg : EMBO Press, 2018 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 4(2021), 11, Artikel-ID e202101199, Seite 1-15 |
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| ISSN Quelle: | 2575-1077 |
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| Abstract: | <p>Proliferation of <i>Plasmodium falciparum</i> in red blood cells is the cause of malaria and is underpinned by an unconventional cell division mode, called schizogony. Contrary to model organisms, <i>P. falciparum</i> replicates by multiple rounds of nuclear divisions that are not interrupted by cytokinesis. Organization and dynamics of critical nuclear division factors remain poorly understood. Centriolar plaques, the centrosomes of <i>P. falciparum</i>, serve as microtubule organizing centers and have an acentriolar, amorphous structure. The small size of parasite nuclei has precluded detailed analysis of intranuclear microtubule organization by classical fluorescence microscopy. We apply recently developed super-resolution and time-lapse imaging protocols to describe microtubule reconfiguration during schizogony. Analysis of centrin, nuclear pore, and microtubule positioning reveals two distinct compartments of the centriolar plaque. Whereas centrin is extranuclear, we confirm by correlative light and electron tomography that microtubules are nucleated in a previously unknown and extended intranuclear compartment, which is devoid of chromatin but protein-dense. This study generates a working model for an unconventional centrosome and enables a better understanding about the diversity of eukaryotic cell division.</p> |
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| DOI: | doi:10.26508/lsa.202101199 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.26508/lsa.202101199 |
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| | Volltext: https://www.life-science-alliance.org/content/4/11/e202101199 |
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| | DOI: https://doi.org/10.26508/lsa.202101199 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1777289017 |
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| Verknüpfungen: | → Zeitschrift |
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¬An¬ extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites / Simon, Caroline [VerfasserIn]; 17 September 2021 (Online-Ressource)
