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| Verfasst von: | Schneider, Markus [VerfasserIn]  |
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| | Munder, Markus [VerfasserIn] |
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| | Karakhanova, Svetlana [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Görner, Martin [VerfasserIn] |
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| Titel: | The initial phase of graft-versus-host disease is associated with a decrease of CD4+CD25+ regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation |
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| Verf.angabe: | M. Schneider, M. Munder, S. Karakhanova, A.D. Ho, M. Goerner |
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| E-Jahr: | 2006 |
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| Jahr: | 09 November 2006 |
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| Umfang: | 9 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Die Pluszeichen im Titel sind hochgestellt ; Gesehen am 12.11.2021 |
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| Titel Quelle: | Enthalten in: Clinical and laboratory haematology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1979 |
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| Jahr Quelle: | 2006 |
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| Band/Heft Quelle: | 28(2006), 6, Seite 382-390 |
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| ISSN Quelle: | 1365-2257 |
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| Abstract: | The mechanisms that induce and control the alloimmune inflammation of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (allo-SCT) are still incompletely understood. In the murine system, GvHD can be suppressed by CD4+CD25+ regulatory T cells (TREG), which are generally involved in the suppression of inflammatory reactions. A disruption of the homeostasis between TREG and conventional T cells might therefore be associated with the inflammatory reactions of GvHD. We repetitively measured the frequency of TREG in the peripheral blood of 29 patients within the first 71-373 days after allo-SCT and correlated the results with the clinical course. We demonstrate that the initial phase of GvHD is associated with a significant reduction of TREG in the peripheral blood, while at later stages and during intensified immunosuppressive therapy, increased numbers of TREG appear. These results might indicate a pathogenic role for reduced numbers of TREG in the induction of human GvHD. |
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| DOI: | doi:10.1111/j.1365-2257.2006.00825.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/j.1365-2257.2006.00825.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2257.2006.00825.x |
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| | DOI: https://doi.org/10.1111/j.1365-2257.2006.00825.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | graft-versus-host disease |
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| | human |
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| | immunoregulation |
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| | regulatory T cell |
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| | Stem cell transplantation |
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| K10plus-PPN: | 1777324866 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ initial phase of graft-versus-host disease is associated with a decrease of CD4+CD25+ regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation / Schneider, Markus [VerfasserIn]; 09 November 2006 (Online-Ressource)
