Proposal of a safe and effective study design for CYP3A-mediated drug-drug interactions

• Verfasst von: Rohr, Brit Silja [VerfasserIn]
• Verfasst von: Mikus, Gerd [VerfasserIn]
• Titel: Proposal of a safe and effective study design for CYP3A-mediated drug-drug interactions
• Verf.angabe: Brit Silja Rohr and Gerd Mikus
• Jahr: 2020
• Umfang: 10 S.
• Fussnoten: First published: 21 May 2020 ; Gesehen am 15.11.2021
• Titel Quelle: Enthalten in: Journal of clinical pharmacology
• Ort Quelle: Hoboken, NJ : Wiley, 1961
• Jahr Quelle: 2020
• Band/Heft Quelle: 60(2020), 10, Seite 1294-1303
• ISSN Quelle: 1552-4604
• DOI: doi:10.1002/jcph.1622
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1777449723
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Numerous drug-drug interaction (DDI) trials have to be conducted in healthy volunteers based on current regulatory guidelines. Because the worst-case scenario of strong cytochrome P450 (CYP) inhibitors has to be tested, the results and their validity have to be balanced with the risk to volunteer safety.