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Verfasst von:Bertaina, Maurizio [VerfasserIn]   i
 Nuñez-Gil, Ivan J. [VerfasserIn]   i
 Franchin, Luca [VerfasserIn]   i
 Rozas, Inmaculada Fernández [VerfasserIn]   i
 Arroyo-Espliguero, Ramón [VerfasserIn]   i
 Viana-Llamas, María C. [VerfasserIn]   i
 Romero, Rodolfo [VerfasserIn]   i
 Eid, Charbel Maroun [VerfasserIn]   i
 Uribarri, Aitor [VerfasserIn]   i
 Becerra-Muñoz, Víctor Manuel [VerfasserIn]   i
 Huang, Jia [VerfasserIn]   i
 Alfonso, Emilio [VerfasserIn]   i
 Marmol-Mosquera, Fernando [VerfasserIn]   i
 Ugo, Fabrizio [VerfasserIn]   i
 Cerrato, Enrico [VerfasserIn]   i
 Fernandez-Presa, Lucia [VerfasserIn]   i
 Roubin, Sergio Raposeiras [VerfasserIn]   i
 Guzman, Gisela Feltes [VerfasserIn]   i
 Gonzalez, Adelina [VerfasserIn]   i
 Abumayyaleh, Mohammad S. A. [VerfasserIn]   i
 Fernandez-Ortiz, Antonio [VerfasserIn]   i
 Macaya, Carlos [VerfasserIn]   i
 Estrada, Vicente [VerfasserIn]   i
Titel:Non-invasive ventilation for SARS-CoV-2 acute respiratory failure
Titelzusatz:a subanalysis from the HOPE COVID-19 registry
Verf.angabe:Maurizio Bertaina, Ivan J. Nuñez-Gil, Luca Franchin, Inmaculada Fernández Rozas, Ramón Arroyo-Espliguero, María C. Viana-Llamas, Rodolfo Romero, Charbel Maroun Eid, Aitor Uribarri, Víctor Manuel Becerra-Muñoz, Jia Huang, Emilio Alfonso, Fernando Marmol-Mosquera, Fabrizio Ugo, Enrico Cerrato, Lucia Fernandez-Presa, Sergio Raposeiras Roubin, Gisela Feltes Guzman, Adelina Gonzalez, Mohammad Abumayyaleh, Antonio Fernandez-Ortiz, Carlos Macaya, Vicente Estrada
E-Jahr:2021
Jahr:16 March 2021
Umfang:7 S.
Fussnoten:Gesehen am 15.11.2021
Titel Quelle:Enthalten in: Emergency medicine journal
Ort Quelle:London : BMJ Publ. Group, 2001
Jahr Quelle:2021
Band/Heft Quelle:38(2021), 5, Seite 359-365
ISSN Quelle:1472-0213
Abstract:Background The COVID-19 pandemic has seriously challenged worldwide healthcare systems and limited intensive care facilities, leading to physicians considering the use of non-invasive ventilation (NIV) for managing SARS-CoV-2-related acute respiratory failure (ARF). - Methods We conducted an interim analysis of the international, multicentre HOPE COVID-19 registry including patients admitted for a confirmed or highly suspected SARS-CoV-2 infection until 18 April 2020. Those treated with NIV were considered. The primary endpoint was a composite of death or need for intubation. The components of the composite endpoint were the secondary outcomes. Unadjusted and adjusted predictors of the primary endpoint within those initially treated with NIV were investigated. - Results 1933 patients who were included in the registry during the study period had data on oxygen support type. Among them, 390 patients (20%) were treated with NIV. Compared with those receiving other non-invasive oxygen strategy, patients receiving NIV showed significantly worse clinical and laboratory signs of ARF at presentation. Of the 390 patients treated with NIV, 173 patients (44.4%) met the composite endpoint. In-hospital death was the main determinant (147, 37.7%), while 62 patients (15.9%) needed invasive ventilation. Those requiring invasive ventilation had the lowest survival rate (41.9%). After adjustment, age (adjusted OR (adj(OR)) for 5-year increase: 1.37, 95% CI 1.15 to 1.63, p<0.001), hypertension (adj(OR) 2.95, 95% CI 1.14 to 7.61, p=0.03), room air O2 saturation <92% at presentation (adj(OR) 3.05, 95% CI 1.28 to 7.28, p=0.01), lymphocytopenia (adj(OR) 3.55, 95% CI 1.16 to 10.85, p=0.03) and in-hospital use of antibiotic therapy (adj(OR) 4.91, 95% CI 1.69 to 14.26, p=0.003) were independently associated with the composite endpoint. - Conclusion NIV was used in a significant proportion of patients within our cohort, and more than half of these patients survived without the need for intubation. NIV may represent a viable strategy particularly in case of overcrowded and limited intensive care resources, but prompt identification of failure is mandatory to avoid harm. Further studies are required to better clarify our hypothesis. - Trial registration numbers NCT04334291/EUPAS34399.
DOI:doi:10.1136/emermed-2020-210411
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1136/emermed-2020-210411
 Volltext: https://emj.bmj.com/content/38/5/359
 DOI: https://doi.org/10.1136/emermed-2020-210411
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:acute care
 COVID-19
 non-invasive
 respiratory
 ventilation
K10plus-PPN:1777455472
Verknüpfungen:→ Zeitschrift

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