In glioma, all endothelial cells are not created the same

• Verfasst von: Winkler, Frank [VerfasserIn]
• Titel: In glioma, all endothelial cells are not created the same
• Verf.angabe: Frank Winkler
• E-Jahr: 2021
• Jahr: 11 March 2021
• Umfang: 2 S.
• Fussnoten: Gesehen am 16.11.2021
• Titel Quelle: Enthalten in: Neuro-Oncology
• Ort Quelle: Oxford : Oxford Univ. Press, 1999
• Jahr Quelle: 2021
• Band/Heft Quelle: 23(2021), 6, Seite 863-864
• ISSN Quelle: 1523-5866
• DOI: doi:10.1093/neuonc/noab065
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1777518369

Abstract

See the article by Carlson et al. in this issue, pp. 932-944.Blood vessels in primary and metastatic brain tumors have long attracted the attention of researchers and clinicians alike. They can be abundant, with frank angiogenesis primarily governed by VEGF and angiopoietins,1-3 or cooption of existing brain vessels, and show a marked irregularity in structure and function which makes them considerably different from the well-organized and tightly orchestrated blood vessels of the normal brain. However, while angiogenesis in brain metastasis remains an interesting therapeutic and even preventive target with some clinical relevance,2,3 the failure of phase III clinical trials to demonstrate an overall survival benefit of anti-VEGF-A therapy in glioblastoma and other gliomas has lately cooled down the excitement about (anti-)angiogenesis and generally blood vessel biology in Neuro-Oncology. This recent lack of enthusiasm needs to be challenged. It is clear today that blood vessels play a crucial biological role in glioma, too. Tumor cells intimately interact with the blood vessel wall to invade the surrounding brain parenchyma.4 Residence directly at or in the vascular wall, the so-called perivascular niche, promotes glioma cell stemness, self-repair capabilities, and tumor cell resistance against radio- and chemotherapy.5 Therefore, much more needs to be learned about blood vessel biology in glioma, and more translationally relevant findings in the future can be expected.