Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Graf, Fabian [VerfasserIn]   i
 Horn, Patrick [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Boutros, Michael [VerfasserIn]   i
 Maercker, Christian [VerfasserIn]   i
Titel:The extracellular matrix proteins type I collagen, type III collagen, fibronectin, and laminin 421 stimulate migration of cancer cells
Verf.angabe:Fabian Graf, Patrick Horn, Anthony D. Ho, Michael Boutros, Christian Maercker
E-Jahr:2021
Jahr:12 June 2021
Umfang:16 S.
Titel Quelle:Enthalten in: Federation of American Societies for Experimental BiologyThe FASEB journal
Ort Quelle:Hoboken, NJ : Wiley, 1987
Jahr Quelle:2021
Band/Heft Quelle:35(2021), 7, Artikel-ID 21692, Seite 1-16
ISSN Quelle:1530-6860
Abstract:For metastasis formation, individual cells from a primary tumor must migrate toward other tissues. The aim of this study was to determine if mesenchymal stromal cells (MSCs) from human bone marrow are able to emit signals that induce this migratory activity in cancer cells. We separated the supernatant of MSCs derived from human bone marrow by size-exclusion and ion-exchange chromatography and have subsequently studied the migratory behavior of the prostate cancer cell line PC3 and the breast cancer cell line MDA-MB-231 toward the respective fractions in a transwell migration assay. We identified the extracellular matrix (ECM) proteins type I collagen, type III collagen, fibronectin, and laminin 421 as potential drivers of cancer cell migration. These results could be reproduced using the corresponding isolated or recombinant ECM proteins. Knockdown of the gene encoding beta 1 integrin, an important cell surface receptor for fibronectin, has led to inhibition of cancer cell migration. This supports the hypothesis that beta 1 integrin signaling represents an initial event that leads to metastasis, and that signaling is triggered by binding of integrin heterodimers to ECM molecules. Further characterization of signaling factors and their respective receptors will have implications for anticancer drug development.
DOI:doi:10.1096/fj.202002558RR
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1096/fj.202002558RR
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1096/fj.202002558RR
 DOI: https://doi.org/10.1096/fj.202002558RR
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cancer cell migration
 extracellular matrix proteins
K10plus-PPN:1777636329
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68802501   QR-Code
zum Seitenanfang