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Verfasst von:Wirotanseng, Laura Nikita [VerfasserIn]   i
 Kuner, Rohini [VerfasserIn]   i
 Tappe-Theodor, Anke [VerfasserIn]   i
Titel:Gq rather than G11 preferentially mediates nociceptor sensitization
Verf.angabe:Laura Nikita Wirotanseng, Rohini Kuner and Anke Tappe-Theodor
E-Jahr:2013
Jahr:25 October 2013
Umfang:6 S.
Fussnoten:Im Titel ist "q" und "11" jeweils tiefgestellt ; Gesehen am 18.11.2021
Titel Quelle:Enthalten in: Molecular pain
Ort Quelle:London : Sage, 2005
Jahr Quelle:2013
Band/Heft Quelle:9(2013), Artikel-ID 54, Seite 1-6
ISSN Quelle:1744-8069
Abstract:Background: The Gq/11-protein signaling mechanism is essential throughout the nervous system, but little is known about the contribution of the individual G-protein GPCR signaling branches towards nociceptor activation and their specific role on nociceptor sensitization. We aimed to unravel the contribution of the Gq/11-signaling pathway towards nociceptor activation via a variety of classical inflammatory mediators signalling via different G-protein GPCRs and investigated the specific contribution of the individual Gq and G11, G-Proteins in nociceptors. Findings: Using different transgenic mouse lines, lacking Gαq, Gα11, or both α-subunit of the G-proteins in primary nociceptive neurons, we analyzed the mechanical- and heat-sensitivity upon application of different GPCR-agonists that are known to play an important role under inflammatory conditions (e.g. ATP, Glutamate, Serotonin etc.). We found that the Gq/11-GPCR signaling branch constitutes a primary role in the manifestation of mechanical allodynia and a minor role in the development of thermal hyperalgesia. Moreover, with respect to the mediators used here, the Gq-protein is the principle G-protein among the Gq/11-protein family in nociceptive neurons leading to nociceptor sensitization. Conclusions: Our results demonstrate that the Gq/11 signaling branch plays a primary role in nociceptor sensitization upon stimulation with classical GPCR ligands, contributing primarily towards the development of mechanically allodynia. Moreover, the deletion of the individual G-proteins led to the finding that the Gq-protein dominates the signalling machinery of the Gq/11 family of G-proteins in nociceptive neurons.
DOI:doi:10.1186/1744-8069-9-54
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1186/1744-8069-9-54
 DOI: https://doi.org/10.1186/1744-8069-9-54
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:177791924X
Verknüpfungen:→ Zeitschrift

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