Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Wirotanseng, Laura Nikita [VerfasserIn]  |
| Kuner, Rohini [VerfasserIn]  |
| Tappe-Theodor, Anke [VerfasserIn]  |
Titel: | Gq rather than G11 preferentially mediates nociceptor sensitization |
Verf.angabe: | Laura Nikita Wirotanseng, Rohini Kuner and Anke Tappe-Theodor |
E-Jahr: | 2013 |
Jahr: | 25 October 2013 |
Umfang: | 6 S. |
Fussnoten: | Im Titel ist "q" und "11" jeweils tiefgestellt ; Gesehen am 18.11.2021 |
Titel Quelle: | Enthalten in: Molecular pain |
Ort Quelle: | London : Sage, 2005 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 9(2013), Artikel-ID 54, Seite 1-6 |
ISSN Quelle: | 1744-8069 |
Abstract: | Background: The Gq/11-protein signaling mechanism is essential throughout the nervous system, but little is known about the contribution of the individual G-protein GPCR signaling branches towards nociceptor activation and their specific role on nociceptor sensitization. We aimed to unravel the contribution of the Gq/11-signaling pathway towards nociceptor activation via a variety of classical inflammatory mediators signalling via different G-protein GPCRs and investigated the specific contribution of the individual Gq and G11, G-Proteins in nociceptors. Findings: Using different transgenic mouse lines, lacking Gαq, Gα11, or both α-subunit of the G-proteins in primary nociceptive neurons, we analyzed the mechanical- and heat-sensitivity upon application of different GPCR-agonists that are known to play an important role under inflammatory conditions (e.g. ATP, Glutamate, Serotonin etc.). We found that the Gq/11-GPCR signaling branch constitutes a primary role in the manifestation of mechanical allodynia and a minor role in the development of thermal hyperalgesia. Moreover, with respect to the mediators used here, the Gq-protein is the principle G-protein among the Gq/11-protein family in nociceptive neurons leading to nociceptor sensitization. Conclusions: Our results demonstrate that the Gq/11 signaling branch plays a primary role in nociceptor sensitization upon stimulation with classical GPCR ligands, contributing primarily towards the development of mechanically allodynia. Moreover, the deletion of the individual G-proteins led to the finding that the Gq-protein dominates the signalling machinery of the Gq/11 family of G-proteins in nociceptive neurons. |
DOI: | doi:10.1186/1744-8069-9-54 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1186/1744-8069-9-54 |
| DOI: https://doi.org/10.1186/1744-8069-9-54 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 177791924X |
Verknüpfungen: | → Zeitschrift |
Gq rather than G11 preferentially mediates nociceptor sensitization / Wirotanseng, Laura Nikita [VerfasserIn]; 25 October 2013 (Online-Ressource)
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