| Online-Ressource |
Verfasst von: | Plate, Johannes [VerfasserIn]  |
| Wiggins, Walter F. [VerfasserIn]  |
| Haubruck, Patrick [VerfasserIn]  |
| Scott, Aaron T. [VerfasserIn]  |
| Smith, Thomas L. [VerfasserIn]  |
| Saul, Katherine R. [VerfasserIn]  |
| Mannava, Sandeep [VerfasserIn]  |
Titel: | Normal aging alters in vivo passive biomechanical response of the rat gastrocnemius-Achilles muscle-tendon unit |
Verf.angabe: | Johannes F. Plate, Walter F. Wiggins, Patrick Haubruck, Aaron T. Scott, Thomas L. Smith, Katherine R. Saul, Sandeep Mannava |
Jahr: | 2013 |
Umfang: | 6 S. |
Fussnoten: | Available online 13 December 2012 ; Gesehen am 25.11.2021 |
Titel Quelle: | Enthalten in: Journal of biomechanics |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1968 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 46(2013), 3 vom: 1. Feb., Seite 450-455 |
ISSN Quelle: | 1873-2380 |
Abstract: | Predisposition to Achilles tendon (AT) ruptures in middle-aged individuals may be associated with age-related changes to inherent passive biomechanical properties of the gastrocnemius-Achilles (GC-AT) muscle-tendon unit, due to known muscle-tendon structural changes in normal aging. The goal of this study was to determine whether the passive biomechanical response of the GC-AT muscle-tendon unit was altered with age in 6 young (8 months) and 6 middle-aged (24 months) F344xBN hybrid rats from the National Institute on Aging colony. Fung's quasilinear viscoelastic (QLV) model was used to determine in vivo history and time-dependent load-relaxation response of the GC-AT. Effective stiffness and modulus were also estimated using linear regression analysis. Fung's QLV revealed a significantly decreased magnitude of the relaxation response (parameter C, p=0.026) in middle-aged animals compared to young animals (0.108±0.007 vs. 0.144±0.015), with similar time-dependent viscous GC-AT properties (τ1, τ2). The product of elastic parameters (A⁎B), which represents the initial slope of the elastic response, was significantly increased by 50% in middle-aged rats (p=0.014). Estimated GC-AT stiffness increased 28% at peak tensions in middle-aged rats (2.7±0.2N/mm) compared to young rats (1.9±0.2N/mm; p=0.036). While the limitations of this animal model must be considered, the changes we describe could be associated with the observation that GC-AT pathology and injury is more common in middle-aged individuals. Further studies are necessary to characterize the load-to-failure behavior of AT in middle-aged compared to young animals. |
DOI: | doi:10.1016/j.jbiomech.2012.11.007 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jbiomech.2012.11.007 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0021929012006598 |
| DOI: https://doi.org/10.1016/j.jbiomech.2012.11.007 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Achilles tendon rupture |
| Aging |
| Fung QLV |
| Passive biomechanical properties |
| Quasilinear viscoelastic |
K10plus-PPN: | 1779073437 |
Verknüpfungen: | → Zeitschrift |
Normal aging alters in vivo passive biomechanical response of the rat gastrocnemius-Achilles muscle-tendon unit / Plate, Johannes [VerfasserIn]; 2013 (Online-Ressource)