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Status: Bibliographieeintrag

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Verfasst von:Plate, Johannes [VerfasserIn]   i
 Wiggins, Walter F. [VerfasserIn]   i
 Haubruck, Patrick [VerfasserIn]   i
 Scott, Aaron T. [VerfasserIn]   i
 Smith, Thomas L. [VerfasserIn]   i
 Saul, Katherine R. [VerfasserIn]   i
 Mannava, Sandeep [VerfasserIn]   i
Titel:Normal aging alters in vivo passive biomechanical response of the rat gastrocnemius-Achilles muscle-tendon unit
Verf.angabe:Johannes F. Plate, Walter F. Wiggins, Patrick Haubruck, Aaron T. Scott, Thomas L. Smith, Katherine R. Saul, Sandeep Mannava
Jahr:2013
Umfang:6 S.
Fussnoten:Available online 13 December 2012 ; Gesehen am 25.11.2021
Titel Quelle:Enthalten in: Journal of biomechanics
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1968
Jahr Quelle:2013
Band/Heft Quelle:46(2013), 3 vom: 1. Feb., Seite 450-455
ISSN Quelle:1873-2380
Abstract:Predisposition to Achilles tendon (AT) ruptures in middle-aged individuals may be associated with age-related changes to inherent passive biomechanical properties of the gastrocnemius-Achilles (GC-AT) muscle-tendon unit, due to known muscle-tendon structural changes in normal aging. The goal of this study was to determine whether the passive biomechanical response of the GC-AT muscle-tendon unit was altered with age in 6 young (8 months) and 6 middle-aged (24 months) F344xBN hybrid rats from the National Institute on Aging colony. Fung's quasilinear viscoelastic (QLV) model was used to determine in vivo history and time-dependent load-relaxation response of the GC-AT. Effective stiffness and modulus were also estimated using linear regression analysis. Fung's QLV revealed a significantly decreased magnitude of the relaxation response (parameter C, p=0.026) in middle-aged animals compared to young animals (0.108±0.007 vs. 0.144±0.015), with similar time-dependent viscous GC-AT properties (τ1, τ2). The product of elastic parameters (A⁎B), which represents the initial slope of the elastic response, was significantly increased by 50% in middle-aged rats (p=0.014). Estimated GC-AT stiffness increased 28% at peak tensions in middle-aged rats (2.7±0.2N/mm) compared to young rats (1.9±0.2N/mm; p=0.036). While the limitations of this animal model must be considered, the changes we describe could be associated with the observation that GC-AT pathology and injury is more common in middle-aged individuals. Further studies are necessary to characterize the load-to-failure behavior of AT in middle-aged compared to young animals.
DOI:doi:10.1016/j.jbiomech.2012.11.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.jbiomech.2012.11.007
 Volltext: https://www.sciencedirect.com/science/article/pii/S0021929012006598
 DOI: https://doi.org/10.1016/j.jbiomech.2012.11.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Achilles tendon rupture
 Aging
 Fung QLV
 Passive biomechanical properties
 Quasilinear viscoelastic
K10plus-PPN:1779073437
Verknüpfungen:→ Zeitschrift

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