Potential risk of food-drug interactions

• Verfasst von: Bajraktari-Sylejmani, Gzona [VerfasserIn]
• Verfasst von: Weiß, Johanna [VerfasserIn]
• Titel: Potential risk of food-drug interactions
• Titelzusatz: citrus polymethoxyflavones and flavanones as inhibitors of the organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1
• Verf.angabe: Gzona Bajraktari-Sylejmani, Johanna Weiss
• E-Jahr: 2020
• Jahr: 13 July 2020
• Umfang: 7 S.
• Fussnoten: Gesehen am 25.11.2021
• Titel Quelle: Enthalten in: European journal of drug metabolism and pharmacokinetics
• Ort Quelle: Cham : Springer Internat. Publ., 1976
• Jahr Quelle: 2020
• Band/Heft Quelle: 45(2020), 6, Seite 809-815
• ISSN Quelle: 2107-0180
• DOI: doi:10.1007/s13318-020-00634-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1779112483
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Citrus flavonoids are not only components of daily nutrition, they are also promoted as dietary supplements and are important ingredients in traditional medicines. Interactions of flavonoids with synthetic drugs represent an often neglected issue. We therefore investigated in vitro whether the polymethoxyflavones nobiletin, sinensetin, and tangeretin and the flavonoid rutinosides didymin, hesperidin, and narirutin can inhibit human organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1, which are important transporters mediating drug-drug and food-drug interactions.