Status: Bibliographieeintrag
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| Verfasst von: | Behrouz, Somayeh [VerfasserIn]  |
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| | Kühl, Nikos [VerfasserIn] |
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| | Klein, Christian D. [VerfasserIn] |
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| Titel: | A facile approach towards amidinophenylalanine derivatives as building blocks for the synthesis of non-natural peptides and peptidomimetics |
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| Verf.angabe: | Somayeh Behrouz, Nikos Kühl, Christian D. Klein |
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| E-Jahr: | 2021 |
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| Jahr: | 22 August 2021 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 26.11.2021 |
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| Titel Quelle: | Enthalten in: Tetrahedron letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1959 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 81(2021), Artikel-ID 153342, Seite 1-7 |
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| ISSN Quelle: | 1873-3581 |
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| Abstract: | The amidine function is extensively utilized as synthetic intermediate for structurally diverse heterocycles and as a core element in drugs and drug candidates. This study describes a facile and convenient approach for the highly efficient synthesis of amidinophenylalanine derivatives via the reduction of amidoximophenylalanines in the presence of Ac2O/AcOH/Zn at room temperature. The described process is attractive for process and medicinal chemistry due to its facility, safety, low cost, applicability for hydrogenation-sensitive compounds, and efficiency. Using this method, amidinophenylalanine derivatives as building blocks for peptides were obtained in excellent yields. |
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| DOI: | doi:10.1016/j.tetlet.2021.153342 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.tetlet.2021.153342 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0040403921006006 |
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| | DOI: https://doi.org/10.1016/j.tetlet.2021.153342 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Amidines |
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| | Amidoximes |
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| | Phenylalanine derivatives |
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| | Reduction |
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| | Zinc |
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| K10plus-PPN: | 1779374739 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ facile approach towards amidinophenylalanine derivatives as building blocks for the synthesis of non-natural peptides and peptidomimetics / Behrouz, Somayeh [VerfasserIn]; 22 August 2021 (Online-Ressource)
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